Acta Physiologica 2011; Volume 202, Supplement 684
The Joint Conference (FAMÉ 2011) of the LXXVth Meeting of the Hungarian Physiological Society, XVIth Meeting of the Hungarian Society of Anatomists, Experimental Section of the Hungarian Society for Experimental and Clinical Pharmacology and Hungarian Society for Microcirculation and Vascular Biology
THE POSSIBLE BENEFIT OF BLOOD MICROPARTICLE MEASUREMENTS IN FUNGAL SEPSIS
Abstract number: P95
Woth1,2 G., Tokes-Fuzesi2 M., Magyarlaki2 T., Krupp1 M., Ernyey1 B., Peto1 E., Kovacs2 L. G., Bogar1 L., Muhl1 D.
The role of platelets in early host defence is long debated. The aim of this study was to assess whether platelet microparticle (MP) number changes can predict the development of fungal sepsis during intensive care unit stay.
We have examined severe septic patients (n=33, 2 or more organ dysfunctions and procalcitonin levels 5 ng/ml or above) and followed MP number changes on admission (1st day) and the following 3rd and 5th days. For microbiological identification, multiple specimens (hemoculture, bronchial lavage fluid and urine) were collected on admission and in case of overall status deterioration. MP measurements were carried out using flow cytometry. Twenty volunteers were invited to determine healthy baseline values.
Fungal septic patients showed elevated Annexin V positive MP number throughout our study which was significant on the 1st day (p < 0.05). The constitutive platelet marker (CD41) positive MP numbers were statistically elevated on the 1st day (p < 0.05). CD42a+ adhesive marker positive vesicles were negligible in the non-fungal group, while fungal septic patients showed significantly elevated numbers in all measurements (p < 0.01). The activated platelet fibrinogen receptor (PAC1) harbouring MPs had elevated numbers in the fungal septic group on the 1st and 5th study days compared to non-fungal septic patients (p < 0.05).
The rapid measurement of CD42a and PAC1 positive MPs on admission can possibly help to improve therapy thus overall outcome of severe septic patients.
To cite this abstract, please use the following information:
Acta Physiologica 2011; Volume 202, Supplement 684 :P95