Acta Physiologica 2011; Volume 202, Supplement 684
The Joint Conference (FAMÉ 2011) of the LXXVth Meeting of the Hungarian Physiological Society, XVIth Meeting of the Hungarian Society of Anatomists, Experimental Section of the Hungarian Society for Experimental and Clinical Pharmacology and Hungarian Society for Microcirculation and Vascular Biology
THE EFFECT OF TYR-D-ALA-GLY-PHE-D-NLE-ARG-PHE, A SYNTHETIC OPIATE ON THE HORMONAL AND BEHAVIORAL STRESS RESPONSE
Abstract number: P13
Csabafi1 K., Jaszberenyi1 M., Bagosi1 Zs., Liptak1 N., Toth2 G., Wollemann2 M., Telegdy1 Gy.
The neuroendocrine and behavioral actions of a synthetic derivative of the endogenous opiate Met5-enkephalin-Arg6-Phe7 were investigated in mice.
The effect of Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe (DADN) on the hormonal aspect of the stress response was assessed by measuring the plasma corticosterone level. The behavior of the animals were observed in an open field apparatus, where the horizontal and vertical locomotion were monitored separately. To identify the receptors involved in the mediation of its actions, pretreatment with the nonselective opioid antagonist naloxone, the selective k-receptor antagonist nor-binaltorphimine and the m1-receptor blocker naloxonazine was preformed.
DADN induced a significant elevation of the plasma corticosterone level, which was antagonized by the preadministration of naloxone and naloxonazine. Also a marked activation was observed in the locomotor and rearing activity, which proved to be naloxone and naloxonazine reversible. The k-receptor selective antagonist was ineffective in both behavioral and endocrine experiments.
These results indicate predominant m-receptor mediation in the neuroendocrine actions of DADN.
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Acta Physiologica 2011; Volume 202, Supplement 684 :P13