Aims: 

To study the molecular composition and function of the photoreceptor ribbon synapse of the mammalian retina, one of the most complex chemical synapses found in the CNS. Photoreceptor ribbon synapses are specialized to release the neurotransmitter glutamate continuously and with high temporal precision over a wide dynamic range of light intensities. Malfunctions at the photoreceptor ribbon synapses can cause impaired vision, or even total blindness.

Methods: 

The structure and function of the photoreceptor ribbon synapses was studied with molecular and biochemical methods, with light and electron microscopic immunocytochemistry, and with electroretinographic recordings.

Results: 

Our studies show that sophisticated macromolecular signaling complexes at the pre- and postsynaptic region of the photoreceptor ribbon synaptic complex govern neurotransmitter release and reception.

Conclusion: 

The detailed molecular knowledge of the photoreceptor ribbon synaptic function is the basis for a better understanding of the physiology and pathophysiology of this unique chemical synapse, and the prerequisite for the development of therapeutic strategies to help restore vision in patients that suffer from degenerative retinal diseases.

Support: 

DFG (Deutsche Forschungsgemeinschaft)