Recent functional imaging studies on chronic pain from different organic etiologies showed significant alterations of both the spatial as well as the temporal dimension of the human brain's functional connectivity during a resting state compared to healthy controls. However, it remains unclear if similar changes in these so-called intrinsic connectivity networks (ICN's) also occur under medically unexplained chronic pain for which has been conceptualized as pain predominant multisomatoform disorder (PPMD) since adequate examination does not reveal sufficiently explanatory structural or other specified pathology. To test this hypothesis, 21 patients suffering from this mental disease and 19 age- and gender-matched controls underwent functional 3T-fMRI scanning. As a parameter able to synoptically describe alterations in functional architecture, the frequency of the spontaneous neural activity was analyzed. Independent component analysis (ICA) and power-spectra analysis led to the following results: Whereas in the healthy brain fronto-insular network (FIN), default mode network (DMN), sensomotor network (SMN) and right frontoparietal network (rFPN) predominantly oscillated at lower frequencies (0 to 0.08 Hz), the intrinsic neural activity of somatoform pain patients showed significantly faster spontaneous fluctuations (0.16 - 0.24 Hz). This striking similarity between PPMD and medically explicable chronic pain supports the notion that pain chronification is a self-sustaining and putatively endogenous mental process decoupled from peripheral organic pathology which severely affects the human brain's connectome in domain general manner.