Aim: 

The psoriasis is skin diseases associated to oxidative stress and increased free radical. In the our previous work we demonstrate the positive organic matrix effect of Guardia Piemontese-Acquappesa (CS) Italy on the psoriasis symptoms. The aim of this work is to evaluate the systemic effect of same organic matrix treatment on the red blood cell of the psoriatic patients.

Methods: 

The RBC membrane integrity is evaluated by the fluorescence polarization method.The degradation of membrane lipids is obtained by determination the MDA-TBA (malondialdehyde-thiobarbituric acid) derivatives. Anion permeability was evaluated by the specific absorption of methemoglobin (CM).The assessment of the degree of haemolysis of erythrocyte membranes is performed by measuring the fragility of membranes induced by radical AAPH [2,2'-azo-bis(2-amidinopropane)dihydrochloride].

Results: 

The 12 days treatment with organic matrix restores significantly all the erythrocyte studied parameter.

Conclusion: 

The basis of obtained data it is assumed that the sinergical action of polyphenols, carothene, vitamin A, tocopherols, phytosterols and minerals conteined in the organic matrix, derived by micro-flora, growing in shallow hyper thermal waters at Guardia Piemontese-Acquappesa (CS) Italy.