The pregnant women are considered to be the most vulnerable part of the society subjected to stress conditions. The effects of acute stress happened on the early stages of gestation are of particular interest for early gestational disturbances may interfere in the normal development of pregnancy or result in perinatal pathologies including spontaneous abortion. The aim of the present study was to evaluate the acute hypoxia influence on the behavior and bioamine levels of experimental animals subjected to stress situation. The white rats' females were exposed to acute hypobaric hypoxia, modeled in pressure chamber on altitude of 11500 meters, on the 9-10th day of pregnancy. The hypoxia-induced effects on the behavior were investigated on the first day after hypoxia using "open field" test. Each animal was placed in the field and its behavioral characteristics were visually registered during following 4 minutes: 2 minutes in the silence and darkness (period before stress) - then 1 minute in bright light (stress period) - then 1 more minute in the darkness again (period after stress). The bioamine levels in rat's brain stem and cerebral cortex were determined using fluorescent method 1 hour after hypoxia. We observed that acute hypoxia led to the decrease of horizontal motor activity and rearing especially in after stress period. The pregnant rats exposed to acute hypoxia also showed the increased number of exits to the center and grooming compared to control group during all the period of observation in open field (p < 0,05). The behavioral effects were in good agreement with the significant increase of DA and decrease of NE-levels in the brain stem. According to data observed it seems that hypoxic stress contributes to the development of severe neurological impairment which can affect on the vitality and wealth of future descendants.