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Acta Physiologica Congress

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Acta Physiologica 2010; Volume 198, Supplement 677
Joint Meeting of the Scandinavian and German Physiological Societies
3/27/2010-3/30/2010
Copenhagen, Denmark


ANTENATAL STRESSES OF DIFFERENT ETIOLOGY DURING EARLY ORGANOGENESIS: INTERMISSION POSTNATAL EFFECTS
Abstract number: P-MON-77

TROFIMOVA1 LK, DUNAEVA1 TY, GRAF1 AV, MASLOVA1 MV, KRUSHINSKAYA1 YV, MAKLAKOVA1 AS, CHIRAZOVA1 EE, BAIZHUMANOV1 AA, GONCHARENKO1 EN, KUDRYASHOVA1 NY, SOKOLOVA1 NA

Objective: Different stresses during pregnancy use to change postnatal development of offspring. We compare effects of different stressors in early organogenesis on rats' offspring of early postpubertal age. Methods: Rats on the 9-10th day of pregnancy were subjected to one of the stressors: acute hypobaric hypoxia (AHH, level of O2 was about 5%, rats were divided to low resistant and highly resistant to AHH) or immobilization (IM, throughout 6 hours). We detected the survival rate, weight and behavior (in "Hole board" and "Elevated plus maze"), as well as level of corticosterone in adrenals and blood plasma in 8-week-old males and females. Pups of non-stressed rats were used as control. Results: Only antenatal IM decreased the survival rate (78% vs 94% in control). Males from highly resistant to AHH rats and females from immobilized rats had the decreased weight compared to control (an average of 13 g and 9 g, correspondingly). Behavioral changes were observed in rat pups born from either highly resistant to AHH or immobilized rats. Also females from low resistant to AHH rats had the lower level of corticosterone in adrenals and blood plasma (by 34% and 23%, correspondingly), while females from immobilized rats had the increased hormone level in adrenals (by 44%). In all cases differences were significant at P<0.05. Conclusion: Effects of antenatal stresses of different etiology were observed in rats of early postpubertal period. The most expressed consequences were found in pups from highly resistant rats, survived AHH or rats, survived IM. Nature of consequences depended on stressor type and gender of rat pups.

To cite this abstract, please use the following information:
Acta Physiologica 2010; Volume 198, Supplement 677 :P-MON-77

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