Acta Physiologica 2009; Volume 197, Supplement 672
The 60th National Congress of the Italian Physiological Society
NEURONS WITHIN THE ROSTRO VENTROMEDIAL MEDULLA CONTROL CUTANEOUS VASOMOTION
Abstract number: P171
TUPONE1 D, CERRI1 M, AMICI1 R, DENTICO1 D, LAUDADIO1 S, LUPPI1 M, MARTELLI1 D, MASTROTTO1 M, PEREZ1 E, ZAMBONI1 G
1Dipartimento di Fisiologia Umana e Generale, Universit di Bologna; (Italy)email@example.com
Recent research proposes that putative sympathetic premotor neurons controlling cutaneous vasomotion are located within the rostral ventromedial medulla (RVMM), an area delimited rostrally by the nucleus of the facial nerve (RVMM(fn)) and caudally by the rostral pole of the inferior olive (RVMM(io)). Data from several experiments have shown that cutaneous blood flow is increased by the inhibition and reduced by the activation of neurons within the RVMM(fn), but no data are available on the role of the RVMM(io) on cutaneous vasomotion.
To clarify the role of RVMM(fn) and RVMM(io) neurons in controlling cutaneous vasomotion, microinjection of the GABAA agonist muscimol and GABAA antagonist bicuculline methiodide were performed within the RVMM(fn) or the RVMM(io).
A massive peripheral vasodilatation was evoked by muscimol injection within both the two areas, while disinhibition of either RVMM(fn) or RVMM(io) neurons produced, respectively, a reversal of the increase in cutaneous blood flow induced by warm exposure and an unexpected rapid cutaneous vasodilatation.
The results show that two intermingled sets of neurons are located within the RVMM: a vasoconstrictory and thermoregulatory set, which is tonically active, is located in both the RVMM(io) and the RVMM(fn), while a vasodilatatory and non-thermoregulatory set, which is tonically inhibited, is located in the RVMM(io).
To cite this abstract, please use the following information:
Acta Physiologica 2009; Volume 197, Supplement 672 :P171