Acta Physiologica 2009; Volume 197, Supplement 672
The 60th National Congress of the Italian Physiological Society
CIRCULATING SALICYLIC ACID AND METABOLIC AND INFLAMMATORY RESPONSES AFTER FRUIT INGESTION
Abstract number: P140
RINELLI1 S, SPADAFRANCA1 A, ALICANDRO1 G, FIORILLO1 G, BERTOLI1 S, BATTEZZATI1 A
1International Center for the Assessment of Nutritional Status (ICANS), University of Milansamuele.email@example.com
Food is a complex mixture of macro and micronutrients interacting to produce specific metabolic and inflammatory responses relevant to health status. We hypothesized that fruit meals provide measurable amounts of the anti-inflammatory compounds salicylic (SA) and ferulic acids (FA) and produce different metabolic, endocrine and inflammatory responses compared to the bare fruit macronutrients.
26 healthy young post-absorptive subjects (13M/13F) received 2 meals: peach pulp (0.7 g/kg, 0,94 % fructose, 0,85 % glucose and 7,67% sucrose) and a watery isoglucidic solution (MIX). In the following 3h we measured circulating SA, FA, glucose, insulin, lipid, adiponectin, CRP and Interleukine-6 (IL-6) concentrations.
Basal SA concentrations (0.17±0.03 mmol/L) doubled by 0.5h and peaked at 0,25±0,03 mmol/L at 1.5h after the fruit meal. Basal FA (26,63±3,67 nmol/L) peaked at 0.5h (35,50±7,13 nmol/L) and 1.5h (36,58±3,98 nmol/L) and decreased thereafter. SA and FA concentrations were unchanged after mix. Glucose increased less rapidly with fruit than MIX (+11±1 vs +33±5 mg/dL at 0.25h, p<0.01) and showed a similar profile thereafter. Free fatty acids were more suppressed after fruit (p<0.001). IL-6 increased after both meals (p<0.01) tendentially more with MIX.
SA and FA are normal human serum components provided in measurable amounts by fruit consumption. Components different from the bare macronutrients modulate the metabolic and inflammatory responses to fruit ingestion.
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Acta Physiologica 2009; Volume 197, Supplement 672 :P140