Among the bladder disfunctions, the urgency-frequency syndrome hasn't any specific morphological aspect and so differs from radiation-induced and interstitial cystitis. To study the beneficial effects of the hyperbaric oxygen therapy, 4 women, (mean age 53,2) were submitted to this treatment. At baseline the urination diary reported: 8-10 urinations/day and nocturia 2-3/night.

As for urodynamics: sensitive urgency, normoactive bladder, 1° stimulus 150cc, bladder capacity 250-300cc; urethral burning; normal bulbocavernosus reflex. Cystoscopys revealed 1 bladder glomerulation

Treatment consisted in 20 sessions of HOT 2,5 ATA for 90min.The therapy reduced daily frequency (4-6), burning, and urgency. One case had long lasting effect, 3 relapsed after 1, 5 and 6 months.

While in other cystitis the HOT resolves symptoms and hematuria with the anti-inflammatory action, in these patients the beneficial effects can be attributed to different mechanisms including placebo, reduction (not evident) of inflammation, direct action on the bladder and urethral nervous sensitive fibres and hypothetic central action of the oxigenation.

In conclusion the present data open a research area which connects urology, hyperbaric medicine and physiological research to improve knowledges on this and other urodynamics syndromes.