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Acta Physiologica 2009; Volume 195, Supplement 667
XXXV Congress of The Spanish Society for Physiological Sciences
2/17/2009-2/20/2009
Valencia, Spain
ANDROGEN RECEPTOR POLYMORPHISMS INFLUENCE EXERCISE CAPACITY IN MEN AND WOMEN
Abstract number: P24
Olmedillas1 H, Rodriguez-Gonzalez2,3 FG, Dorado1 C, Guadalupe-Grau1,2,3,4,5,6 A, Guerra1 B, Fuentes1 T, Perez-Gomez4 J, Ara5,6 I, Vicente-Rodriguez5,6 G, Delgado-Guerra1 S, Calbet1 JAL, Diaz-Chico2,3 BN
1Department of Physical Education, University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s/n, Las Palmas de Gran Canaria, 35017, Spain. [email protected].
2Department of Biochemistry and Physiology, Universidad de Las Palmas de Gran Canaria, Spain.
3Canary Islands Cancer Research Institute (ICIC), Las Palmas de Gran Canaria, Canary Islands, Spain.
4Department of Physical Education, University of Extremadura, Faculty of Sport Science, Avd Universidad s/n, Cceres, 10071, Spain.
5GENUD (Growth, Exercise, NUtrition and Development) research group. University of Zaragoza.
6Faculty of Health and Sport Sciences. Department of Physiotherapy and Nursing. University of Zaragoza
Aim:
To test the hypothesis that CAG and GGN repeat AR polymorphism affects muscle mass and performance in humans.
Methods:
Three-hundred forty five subjects (284 men, 61 women; age: 28.8 7.6; 25.4 6.7 years, men and women, respectively), participated in the study. Subjects were genotyped by polymerase chain reaction (PCR) to determine the number of AR CAG and GGN repeats, and grouped as carrying repeat lengths of < 21 (i.e. short allele) or >21 (i.e. long allele) for males CAG; <22 or >22 for females CAG; and <23 or >23 for both males and females GGN. 30-m running sprint, vertical jumps, isometric strength (MVC), an all-out 300-m running test, the VO2max and the body composition (DXA) were determined.
Results:
In the female group, the CAGL tract polymorphism were 2% taller than the CAGs (P<0.05).Although, the MVC per kg of muscle of the lower extremities tended to be higher (+10.6%, P=0.08) in the CAGs, who also run the 300m test 6.7% (P<0.05) faster than CAGL . The whole body lean mass was 7% greater in the women with a shorter CAG (42.5 6.1 vs 39.7 6.1 kg, short and long, respectively, P=0.009).
Conclusion:
Androgen receptor polymorphisms have an influence on whole body lean mass, muscle mass and fitness in healthy adult young women. This association is stronger for the CAG repeat polymorphism than the GGN polymorphism. Neither GGN nor CAG repeat polymorphisms are associated with muscle mass in healthy males.
The study was supported by Ministerio de Educación y Ciencia (DEP2006-56076-C06-04/ACTI) and FEDER, Consejería de Educación, Cultura y Deportes del Gobierno de Canarias (2006/179 0001 and FEDER), Proyecto Interreg IIIB BIOPOLIS, Fundación del Instituto Canario de Investigación del Cáncer (FICIC), Cabildo de Gran Canaria, Cabildo de Tenerife and La Caja de Canarias.
To cite this abstract, please use the following information:
Acta Physiologica 2009; Volume 195, Supplement 667 :P24