The objective of the study was to assess the rate of cold-associated symptoms related to cold- induced vasoconstriction, including Raynaud's phenomenon, in subjects with different adaptability to European North, and to correlate it to functional status of major physiological systems. It has been found that the rate of symptoms based on the cold-induced vasoconstriction, is significantly increased in migrants at the initial period of acclimatization to Nordic environment, and also in the subjects with chronic somatic pathology. Enhanced cold- induced vasoconstriction was shown to correlate with sympathetic skin response that indicates the lack of cholinergic, and the essence of the adrenergic control. Also, enhanced cold-induced vasoconstriction and cold dyspnea were accompanied by changes of pulmonary ventilation and by impairment of sensory and motor nerve conduction. In conclusion, the phenomenon of enhanced cold-induced vasoconstriction appears to be the sign of disadaptation to cold and also the risk factor of health impairment in the Nordic environment.