Glyprolines are the new family of regulatory peptides consisting of glycine and proline [Ashmarin et al., 2002]. Influence of glyprolines beginning from di- to hexaglyprolines (3.7mkmol/kg, per os) on gastric mucosa (GM) homeostasis (H) was studied using ethanol (E), stress (S) and acetate (A)-induced ulcer in male rats. A possibility not only to increase GM stability to E and S but also to accelerate A ulcer healing was shown. All studied glyprolines accelerated A ulcer healing but not all of them increased GM stability to E or S. We supposed that it is connected with vague influence of glyprolines on different peripheral or central mechanisms of ulcerogenesis. As it's known, pathogenesis of E ulcer is mostly determined by peripheral mechanisms and S – by central ones. Only two peptides – Pro-Gly-Pro (PGP) and Gly-Pro-Gly-Pro- Gly-Pro - revealed both protective and therapeutic effects. PGP affects different peripheral and central ulcerogenesis mechanisms. PGP decreases or prevents post-stress disorders of behavior, mesentery microcirculation, mast cells degranulation, testifying its influence on the CNS integrating functions. This glyproline could also exhibit direct protective effects on the cell element of GM itself and also on neural structures involved in the maintenance of GM H: PGP prevents ischemia in gastric tissue induced by indomethacin or E administration, induced a direct vasorelaxant effect, increased the contractive activity of mesenteric lymphatic microvessels, improved rheological properties of blood, decreased vagal-stimulated acid secretion and mast cells degranulation in vitro. So, some glyprolines display protective and curative gastric mucosa antiulcer properties, recovering affected central and peripheral mechanisms of GM H.