Objective: 

The aim of the study was to determine the effects of coenzyme Q10 supplementation on plasma adiponectin, interleukin-6 and tumor necrosis factor-alpha levels in sedentary males.

Methods: 

Fourteen healthy, non-smoker and sedentary males participated in the study. The protocol was approved by the Ethical Committee of the Faculty. This study was a randomized, double blind, crossover trial. From all participants blood samples were collected before coenzyme Q10 or placebo supplementation. The participants were randomly allocated to two groups. Seven participants received oral coenzyme Q10 supplementation, seven participants received placebo (glucose) for 8 weeks. At the end of the 8-week, second blood sampling was performed. After a 4-week washout period, placebo was given to the participants who used coenzyme Q10 first time and vice versa and blood sampling was repeated. Plasma samples were stored at -80°C until the time of analysis for adiponectin, interleukin-6 and tumor necrosis factor-alpha.

Results: 

Neither coenzyme Q10 nor placebo supplementation did affect plasma adiponectin and tumor necrosis factor-alpha levels. Interleukin-6 level increased with coenzyme Q10 supplementation but this increase did not different from that seen with placebo supplementation.

Conclusion: 

Coenzyme Q10 supplementation did not affect plasma adiponectin, interleukin-6 and tumor necrosis factor-alpha levels in sedentary males.