Acta Physiologica 2005; Volume 185, Supplement 649
Belgian Society for Fundamental and Clinical Physiology and Pharmacology, Autumn Meeting 2005
OVEREXPRESSION OF THE ELECTRICALLY SILENT VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV11.1 IN MICE LEADS TO AN INCREASE IN INSULIN SECRETION
Abstract number: ORAL-8
Ottschytsch N., Raes A., Snyders D.
Molecular Biophysics, Physiology and Pharmacology University of Antwerp - Universiteitsplein1 - 2610 Antwerp - Belgium
Kv11.1 encodes a voltage-gated potassium channel subunit belonging to the group of electrically silent Kv subunits, i.e., subunits that do not form functional homotetrameric channels. Kv11.1 has been shown to form heterotetrameric channels with voltage-gated potassium channel Kv2.1, which plays an important modulatory role in the glucose-dependent insulin secretion as it is the major contributor to the repolarization of the pancreatic (-cell. In the present study, we generated transgenic mice in which Kv11.1 is overexpressed to explore the physiological role of Kv11.1. Overexpression of Kv11.1 lead to an increase in insulin secretion which was glucose-independent, suggesting a role of silent channels in the regulation of the resting membrane potential and repolarization in the b-cells of the pancreas. We did not detect additional abnormalities in activity and exploratory behavior, neuromotor performance and cognitive performance. The results are compatible with the hypothesis that overexpression of Kv11.1 displaces the normal silent subunit interacting with Kv2.1 in b-cells.
To cite this abstract, please use the following information:
Acta Physiologica 2005; Volume 185, Supplement 649 :ORAL-8