Sample Syllabus

MOLECULAR GENETICS
Biology 442

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Objectives:

The fast pace of modern molecular genetics research is driven by major challenges in medicine, agriculture, and industry; and, ultimately, by intellectual curiosity. There is intense public interest in the human genome project and genetic engineering, due in part to fascination with how our own genes influence our lives.

The primary objective of this course is to provide students with an advanced understanding and appreciation of current topics in molecular genetics, while developing skills in critical thinking and written expression.

A central theme of the course will be the continuum of biological understanding, starting with basic properties of genes and genomes and extending to the complex, hierarchical interactions fundamental to living organisms. A comprehensive picture of the many ways molecular genetics is being applied to the analysis of complex systems will be developed, including advances that reveal fundamental features of gene regulation during cell growth and differentiation, and in response to a changing environment, as well as developments that are more related to commercial and medical applications. Recent advances in technology, the process and thrill of discovery, and ethical considerations in molecular genetics research will be emphasized.

Grading:

The final grade will be based on two in-class exams, one written assignment, and a final examination. The exams will be in short answer format. Exam I will be worth 20%, Exam II and the written assignment worth 25% each, and the final examination worth 30% of the course grade. 

Lecture Topics

Lecture 1 Overview of course. The beginnings of molecular biology

Lectures 2, 3 The structure of DNA

Lecture 4 Genome organization: From nucleotides to chromatin

Lectures 5, 6 The versatility of RNA

Lectures 7, 8 From gene to protein: The genetic code and protein structure

Lectures 9, 10 DNA replication

Lecture 11 Telomere maintenance

Lectures 12, 13 DNA repair and recombination

Lectures 14, 15, 16 Recombinant DNA technology, molecular cloning, & some tools for analyzing gene expression

EXAM 1 (covering material in Lectures 2–14)

Lectures 17, 18 Transcription in prokaryotes

Lectures 19, 20, 21, 22 Transcription in eukaryotes

Lectures 23, 24, 25, 26 Epigenetics and monoallelic gene expression

EXAM 2 (covering material in Lectures 15–26)

Lectures 27, 28, 29, 30 RNA processing and post-transcriptional gene regulation

Lectures 31, 32 Mechanisms of translation

Lecture 33 Genetically modified organisms: Use in basic and applied research

Lecture 34 Genome analysis: DNA typing

Lecture 35 Genome analysis: Genomics and beyond

WRITTEN ASSIGNMENTS DUE

Lectures 36, 37 Medical molecular biology: Cancer

Lecture 38 Medical molecular biology: Gene therapy

Lecture 39 Genes and behavior

FINAL EXAM (Comprehensive section worth 10% of final grade, section specifically covering Lectures 27–39 worth 20% of final grade)