Arthritis & Rheumatism, Volume 63,
November 2011 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Chicago, Illinois November 4-9, 2011.

Spectrum of Cardiac Lesions in Behet's Disease.

Geri1,  Guillaume, Wechsler1,  Bertrand, Huong1,  Du Le Thi, Isnard2,  Richard, Piette1,  Jean-Charles, Amoura1,  Zahir, Rigon3,  Mathieu Resche

CHU Pitié-Salpêtrière, Paris, France
Department of Cardiology, CHU Pitié-Salpêtrière, 47–83 Boulevard de l'hôpital, 75651 Paris Cedex 13, Paris, France, Paris, France
Department of Internal Medicine and Laboratory I3 "Immunology, Immunopathology, Immunotherapy", UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié-Salpetrière, Université Pierre et Marie Curie, Paris 6, Paris


Behçet's disease (BD) is a multisystemic vasculitis of unknown etiology. Cardiac involvement is rare in BD. Data regarding clinical presentation and outcome of cardiac BD are lacking. The aim of this study was to describe the spectrum of cardiac lesions in a large cohort of patients with BD.


We reported a series of 52 consecutive patients with cardiac involvement fulfilling the international criteria of BD. Multivariate analysis was performed to determine factors associated with complete remission of cardiac involvement in BD.


Among a cohort 807 BD patients, 52 (6.4%) had a cardiac involvement. They were mostly of male gender (86.5%) Mean age at diagnosis was 33.5±16.5 years and cardiac involvement was the first feature of BD in 17 patients (32.7%). Main types of cardiac lesions included pericarditis (n=20; 38.5%), endocardium involvement [mostly aortic insufficiency] (n=14 26.9%), intracardiac thrombosis [right atrium or ventricule] (n=10; 19.2%), myocardial infarction (n=9; 17.3%), endomyocardic fibrosis (n=4, 7.7%) and myocardial aneurysm (n=2, 3.8%). BD patients with cardiac involvement had a higher mortality rate at 5 years compared to those without (16.5% vs 4.2%, p=0.03). Eight patients died after a mean follow up of 3.3±2.7 years [myocardial infarction (n=2), sepsis (n=2), bacterial endocarditis (n=1) and unknown (n=3)]. Large-vessel vasculitis and deep-vein thrombosis occurred more frequently in patients with cardiac involvement than in those without (42.3 vs. 11.1, p<0.0001 and 59.6 vs. 35.8; p<0.005, respectively). Factors associated with complete remission of cardiac involvement were the use of immunosuppressants and colchicin, and oral anticoagulation.


Cardiac lesions involved 6% of our BD patients and are associated with a poor outcome.

To cite this abstract, please use the following information:
Geri, Guillaume, Wechsler, Bertrand, Huong, Du Le Thi, Isnard, Richard, Piette, Jean-Charles, Amoura, Zahir, et al; Spectrum of Cardiac Lesions in Behet's Disease. [abstract]. Arthritis Rheum 2011;63 Suppl 10 :2399

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