Arthritis & Rheumatism, Volume 63,
November 2011 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Chicago, Illinois November 4-9, 2011.

Anti-Cyclic Citrullinated Peptide (Anti-CCP) Antibodies with Brucellosis.

Kisacik1,  Bunyamin, Aydinli1,  Musa, Pehlivan1,  Yavuz, Dag1,  Muhammet sait, Sayarlioglu2,  Mehmet, Onat3,  Ahmet Mesut

Gaziantep, Turkey
Kahramanmaras, Turkey
Gaziantep Universitesi, Gaziantep, Turkey


Brucellosis is a zoonotic disease with a high prevalence that remains world's most commonly seen bacterial zoonosis. The clinical manifestations of brucellosis are similar with various diseases like rheumatic diseases, neurologic diseases and other infectious diseases. Anti-cyclic citrullinated peptide (Anti-CCP) is a highly specific serological marker for rheumatoid arthritis. In this study we have analyzed Anti-CCP and rheumatoid factor (RF) levels of patients with brucellosis.


The study population consist of of 113 patients with brucellosis (male/female: 37/76), 63 patients with hepatitis B (male/female: 30/33), 59 patients with hepatitis C (male/female: 11/48), 46 patients with rheumatoid arthritis (male/female: 16/30) and 49 patients with healthy controls (male/female: 20/29).


Mean ages of patients with brucellosis, HCV, HBV, RA and healthy control subjects were 32.2±10.1, 34.2±8.2, 35.1±9.5, 46,6±11.1, 33.1±7.6 respectively. Artalgia was detected in 20 of 113 patients with brucellosis; arthritis was detected in 74 of 113 patients with brucellosis which was the commonest involvement. Of the 113 patients, 23 patients were mono-arthritis, 44 patients were oligo-arthritis and 7 patients were poly-arthritis. The most commonly affected joints were knee (49 patients, two patients were bilaterally), ankle (33 patients, three patients were bilaterally), hip (15 patients, three patients were bilaterally) and wrist (14 patients, three patients were bilaterally) respectively.The results of the analyses reflect that, anti-CCP was positive in 11.5% and RF was positive in 8.8% of the patients.


This is the first study that demonstrates potential role of anti-CCP in the diagnosis of patients with brucellosis. After a comparative evaluation, we have found out that there was not a statistical significance concerning the Anti-CCP levels between the patients with brucellosis and healthy control.

To cite this abstract, please use the following information:
Kisacik, Bunyamin, Aydinli, Musa, Pehlivan, Yavuz, Dag, Muhammet sait, Sayarlioglu, Mehmet, Onat, Ahmet Mesut; Anti-Cyclic Citrullinated Peptide (Anti-CCP) Antibodies with Brucellosis. [abstract]. Arthritis Rheum 2011;63 Suppl 10 :1951

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