Arthritis & Rheumatism, Volume 63,
November 2011 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Chicago, Illinois November 4-9, 2011.
Association of Body Mass Index, Race/Ethnicity and Gender in a Cohort of Systemic Lupus Erythematosus Patients with Diabetes and/or Hypertension.
Lim1, Jonea, Mushtaq2, Nasir, Aggarwal3, Rachna, Scofield4, R. Hal
Harold Hamm Oklahoma Diabetes Center, University of Oklahoma Health Science Center, Oklahoma City, OK
University of Oklahoma Health Science Center College of Public Health, Oklahoma City, OK
University of Oklahoma Health Science Center; Oklahoma Medical Research Foundation, OK
Oklahoma Medical Research Foundation, Oklahoma City, OK
To determine the prevalence of diabetes mellitus (DM) and/or hypertension (HTN) in systemic lupus erythematosus (SLE) patients and its association with body mass index (BMI). To determine racial/ethnic and gender differences among SLE patients having DM and/or HTN.
In a large cohort of 2044 SLE patients we explored BMI, race/ethnicity and gender as risk factors for development of DM and HTN. All SLE patients met at least four 1982 American College of Rheumatology classification criteria. Chi square and regression techniques were used for this analysis. Statistical analysis was performed on 991 patients for whom we could confirm the diagnosis of DM and HTN after review of medical records of these patients. SAS version 9.1 was used for statistical analysis.
Results of the descriptive analysis showed that 80% (n=789) had HTN, 7% (n=74) DM, and 13% (n=128) had both DM and HTN. Most of the participants (87%) were woman and the majority of them were White (44%) followed by African American (35%). The mean BMI of the sample was 28.93 (SD = 7.85) kg/m2. Table 1 summarizes characteristics of the SLE patients participating in the study. Results of the univariate logistic regression models indicated that there was no statistically significant association of DM with gender or race as compared to those having HTN.
Table 1. Characteristics of the 991 SLE patients participating in the study
|Female||860 (86.78)||68 (91.89)||686 (86.95)||106 (82.81)|
|Male||131 (13.22)||6 (8.11)||103 (13.05)||22 (17.19)|
|White||437 (44.10)||28 (37.84)||359 (45.50)||50 (39.06)|
|African American||344 (34.71)||22 (29.73)||271 (34.35)||51 (39.84)|
|AI/AN||40 (4.04)||6 (8.11)||31 (3.93)||3 (2.34)|
|Others||170 (17.15)||18 (24.32)||128 (16.22)||24 (18.75)|
|BMI mean (sd)||28.93 (7.85)||28.99 (7.91)||28.34 (7.61)||32.65 (8.35)|
Comparison of exclusive DM and exclusive HTN did not show significant association with BMI, however when we compared all DM patients (exclusive DM and both DM and HTN) with exclusive HTN patients there was an association with BMI. SLE patients with higher BMI had increased odds (OR 1.045, 95%CI: 1.0251.065) of having DM. There was no interaction between these variables and the results of the multiple logistic regression analysis showed similar estimates.
Crude and adjusted odds ratios suggested a statistically significant association between BMI and having both DM and HTN. SLE patients having higher BMI were 1.063 (95% CI: 1.0401.087) times more likely to have both DM and HTN when adjusted for gender and race.
Results of analysis of variance indicated that the SLE patients having both DM and HTN had higher mean BMI than those who exclusively had DM (Mean difference = 3.659, 95%CI: 0.9426.377) or HTN (mean difference = 4.314, 95%CI: 2.532, 6.097).
The impact of higher body mass index dominates race/ethnicity and gender association in developing DM and HTN among SLE patients.
To cite this abstract, please use the following information:
Lim, Jonea, Mushtaq, Nasir, Aggarwal, Rachna, Scofield, R. Hal; Association of Body Mass Index, Race/Ethnicity and Gender in a Cohort of Systemic Lupus Erythematosus Patients with Diabetes and/or Hypertension. [abstract]. Arthritis Rheum 2011;63 Suppl 10 :1856