Arthritis & Rheumatism, Volume 63,
November 2011 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Chicago, Illinois November 4-9, 2011.
Frequency of Pulmonary Arterial Hypertension Is Not Increased in Takayasu's Arteritis.
Kalfa1, Melike, Musayev2, Oktay, Emmungil1, Hakan, Soysal3, Ozgul, Yilmaz1, Zevcet, Inal1, Vedat, Akar3, Servet
Dept. of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey
Dept. of Cardiology,Ege University, Izmir, Turkey
Dept. of Internal Medicine, Division of Rheumatology, Dokuz Eylül University, Izmir, Turkey
Takayasu's arteritis (TA) is an inflammatory disease that affects large and medium-sized arteries, especially the aorta and its branches. Although pulmonary artery involvement is common, the clinical manifestation is rare. In this study, we examined the presence of pulmonary arterial hypertension (PAH) in TA patients by using transthoracic Doppler echocardiography.
Seventy patients with TA (mean age 42.07±10.44 years; F/M: 63/7) diagnosed according to the 1990 American College of Rheumatology criteria were enrolled in this study. The control groups included 67 systemic sclerosis (SSc) patients (56.66±11.57 years; F/M:59/8) and 68 healthy controls (39.50±9.53 years; F/M: 61/7). Transthoracic Doppler echocardiography was performed by the same cardiologist to all the participants, and systolic pulmonary artery pressure (SPAP) was calculated for each individual. In accordance to ESC-ERS guideline, possible diagnosis of PAH was considered only in patients having SPAP>50 mmHg, with or without additional echocardiographic findings suggestive of PAH. SPSS 15.0 was used for statistical analysis. P value <0.05 was accepted as statistically significant.
Mean SPAP values in TA, SSc and healthy control groups were 20.93±6.06, 31.57±12.75, and 18.88±5.385 mmHg, respectively. While SPAP values in SSc group were significantly higher than the other two groups (p<0.001), there were no differences between TA and healthy groups (p=0.167). Based upon the ESC-ERS guideline definition, possible PAH was present in 5 out of 67 SSc patients (7.4%). However, although pulmonary artery involvement was present in 4 out of 70 TA patients (5.6%), none of these had PAH.
Using transthoracic Doppler echocardiography and the ESC-ERS guideline, none of our TA patients, including those with pulmonary artery involvement fulfilled the criteria of possible PAH. Although the exact diagnosis of PAH requires classical angiography, our echocardiographic findings suggest that frequency of PAH is not increased in TA.
To cite this abstract, please use the following information:
Kalfa, Melike, Musayev, Oktay, Emmungil, Hakan, Soysal, Ozgul, Yilmaz, Zevcet, Inal, Vedat, et al; Frequency of Pulmonary Arterial Hypertension Is Not Increased in Takayasu's Arteritis. [abstract]. Arthritis Rheum 2011;63 Suppl 10 :1525