Arthritis & Rheumatism, Volume 63,
November 2011 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Chicago, Illinois November 4-9, 2011.

Impairment of the Elastic Properties of Aorta and the Carotid Artery System in Patients with Takayasu's Arteritis.

Yurdakul1,  Selen, Oner2,  Fatma Alibaz, Tayyareci1,  Yelda, Direskeneli2,  Haner, Aytekin1,  Saide

Florence Nightingale Hospital, Istanbul, Turkey
Marmara University, School of Medicine, Istanbul, Turkey


Takayasu's arteritis (TA) is a chronic, inflammatory vasculitis of the aorta and its major branches. In this study, we aimed to evaluate aortic and carotid artery elastic properties and to assess carotid arterial mechanics by using a novel strain imaging method, "velocity vector imaging" (VVI).


We studied 20 patients with TA (F/M:18/2, mean age: 34.8±7.9 years) and 15 healthy controls (HC)(F/M: 14/1, mean age: 33.9±7.0 years). All patients and HC were assessed for aortic strain, stiffness, distensibility, carotid artery stiffness index and carotid artery intima-media thickness (CIMT) measurements. Additionally, VVI analysis was performed to determine longitudinal and radial tissue motion of the common carotid arteries (CCA), by off-line analysis of standard B-mode ultrasound images.


Aortic strain was significantly impaired in patients with TA, compared to the control group (4.8±3.0% vs 14.4±5.5%, p=0.0001), whereas aortic stiffness (8.8±5.1 vs 2.3±1.4, p=0.0001) and carotid artery stiffness index (5.4±2.6 vs 1.7±0.6, p=0.0001) were markedly increased. Similarly, we observed a significant decrease in aortic distensibility in patients with TA (0.9±0.5 vs 1.3±0.5, respectively, p=0.03). Peak longitudinal strain and strain rate values were also significantly impaired in TA (Strain: 1.1±0.3% vs 5.9±0.7%, p=0.011; Strain rate: 0.3±0.1% vs 0.5±0.3, p=0.008). Total longitudinal displacement measurements were similar between the patient group and HC (p=0.13). However, peak radial velocity was decreased (0.1±0.02 cm/s vs 0.3±0.1 cm/s, p=0.02), while time to peak radial velocity was markedly increased in the patient group (208±49 ms vs 139±40 ms, p=0.0001). CIMT was also significantly increased in the patient group (0.1±0.02 cm vs 0.06±0.01 cm, p=0.0001).


TA is associated with reduced elasticity of the aorta and the carotid artery system. Longitudinal and radial wall motion of CCA is also impaired in patients with TA, possibly due to the vascular involvement. VVI is a feasible, novel "strain" imaging method in assessing the mechanical properties of the large arteries in systemic vasculitides.

To cite this abstract, please use the following information:
Yurdakul, Selen, Oner, Fatma Alibaz, Tayyareci, Yelda, Direskeneli, Haner, Aytekin, Saide; Impairment of the Elastic Properties of Aorta and the Carotid Artery System in Patients with Takayasu's Arteritis. [abstract]. Arthritis Rheum 2011;63 Suppl 10 :1509

Abstract Supplement

Meeting Menu