Arthritis & Rheumatism, Volume 63,
November 2011 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Chicago, Illinois November 4-9, 2011.

High Prevalence of Coronary Heart Disease and Its Risk Factors In Veterans with Spondyloarthritides.

Kumar, Suhail, Mains, Trayton, Majithia, Vikas

Background/Purpose:

An increased prevalence of cardiovascular disease (CVD) and coronary heart disease (CHD) has been reported in patients with spondyloarthritides. This study investigated the prevalence of CVD risk factors, CVD including CHD and stroke in veterans at Jackson VAMC with spondyloarthritides (SpA) including PsA, ankylosing spondylitis (AS), and reactive arthritis (ReA).

Methods:

A retrospective chart review, using ICD-9 codes for PsA, AS, and ReA was performed at Jackson, VAMC. Data including age, race, gender, medications, ESR, CRP, lipid panel, HbA1c, 25-OH vitamin D level, hypertension (HTN), smoking, statin use, and CVD events were tabulated. Comparisons of CHD, stroke, and CVD risk factors were made to a matched population from the American Heart Association data. Risk factors included smoking, dyslipidemia (DLD), HTN, and diabetes mellitus (DM). Prevalence ratio and odds ratio were calculated by standard method. Statistical significance (alpha<0.05) was calculated using Chi-square and Fisher's exact test.

Results:

See Table. There were 81 patients, 79 male and 2 female, with mean age of patients with PsA, AS, and ReA being 61.8, 60.4, and 56, respectively. There was significant increase in the prevalence of CHD and the risk factors in the SpA, PsA and AS patients. There was an insufficient number of black patients in the cohort to assess effect of ethnicity.

	Control (%)	SpA (%)	PsA (%)	AS (%)	ReA (%)
CHD	9.1	23.46	25.00	26.09	14.29
PR		2.58	2.75	2.86	NS
OR		3.06	3.33	3.52	NS
p-value		<=0.001	0.01	<0.05	NS
CVA	2.5	3.70	6.82	0	0
PR		1.48 (NS)	2.73 (NS)
DM	7.6	24.69	22.73	26.09	28.57
PR		3.25	2.99	3.43	3.76
HTN	34.4	74.07	77.27	73.91	64.29
PR		2.15	2.25	2.15	1.87
DLD	45.2	82.72	88.64	73.91	78.57
PR		1.83	1.96	1.64	1.74
Smoking	23.1	33.33	36.36	26.09	35.71
PR		1.44	1.57	1.13	1.55
PR, prevalence ratio; OR, odds ratio; NS, not significant

Conclusion:

Our results further confirm that patients with SpA have an increased risk of developing CHD as well its risk factors. Our study is unique as increased risk and its quantification have not been previously reported in the U.S. veteran population. The increased CHD risk attributable to the increased prevalence of risk factors cannot be determined in this study but has been suggested to be over and above in previous studies.

To cite this abstract, please use the following information:
Kumar, Suhail, Mains, Trayton, Majithia, Vikas; High Prevalence of Coronary Heart Disease and Its Risk Factors In Veterans with Spondyloarthritides. [abstract]. Arthritis Rheum 2011;63 Suppl 10 :1286
DOI:

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