Arthritis & Rheumatism, Volume 63,
November 2011 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Chicago, Illinois November 4-9, 2011.
Monocyte Chemoattractant Protein-1 and Pentraxin in Systemic Lupus Erythematosus.
Kiani1, Adnan, Ueland2, Thor, Aukrust2, Pal, Magder3, Laurence S., Hollan4, Ivana, Petri1, Michelle
Pentraxin 3 (PTX3), a member of the same family as C reactive protein, has been shown to be associated with vascular inflammation. Monocyte Chemoattractant Protein-1 (MCP-1) is a chemokine also associated with atherosclerosis. We determined the association of these potential biomarkers with subclinical atherosclerosis measured by coronary artery calcium (CAC), carotid intima-media thickness (IMT) and carotid plaque in SLE at two years followup.
148 SLE patients (91% female, 64% Caucasian, 31% African-American, 5% others, mean age 45 yrs) had measurement of subclinical atherosclerosis (coronary artery calcium CAC, carotid intima-media thickness (IMT) and carotid plaque.
Values of MCP-1 ranged from 34668pg/ml (mean=183, SD=101) and PTX3 from 0.1625ng/ml (mean=2.2, SD=2.6).
Table 1. Shows the association between MCP-1, PTX3 and coronary calcium at baseline.
Table 2. Shows the association between MCP-1, PTX3 and the mean carotid IMT.
|Baseline IMT||Change in IMT|
|Mean IMT||P-value||Mean change from baseline to follow-up||P-value|
Table 3. Shows the association between MCP-1, PTX3 and carotid plaque.
MCP-1 and PTX3 have been associated with atherosclerosis in the general population. In general, the PTX3 levels seen in this study were equivalent to those seen in controls in other studies. MCP-1 and PTX3 in SLE were not associated with any marker of subclinical atherosclerosis. In fact, PTX3 even appeared to be protective against carotid plaque.
To cite this abstract, please use the following information:
Kiani, Adnan, Ueland, Thor, Aukrust, Pal, Magder, Laurence S., Hollan, Ivana, Petri, Michelle; Monocyte Chemoattractant Protein-1 and Pentraxin in Systemic Lupus Erythematosus. [abstract]. Arthritis Rheum 2011;63 Suppl 10 :595