Arthritis & Rheumatism, Volume 63,
November 2011 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Chicago, Illinois November 4-9, 2011.


Low Levels of Vitamin-D are Associated with Neuropathy and Lymphoma Among Patients with Sjgren's Syndrome.

Agmon-Levin1,  Nancy, Amital2,  Howard, Tzioufas3,  Athanasios G., Hoyos4,  Marcus López, Rozman5,  Blaz, Kivity1,  Shaye, Zvi1,  Ilan Ben

Center for Autoimmune Diseases, Sheba Medical Center, Tel-hashomer, Israel, Tel-Hashomer, Israel
Center for Autoimmune Diseases, Sheba Medical Center, Tel-hashomer, Israel, Tel-hashomer, Israel
Medical School-Univ of Athens, Athens, Greece
Servicio Inmunología Hospital Universitario Marqués de Valdecilla Santander Spain, Santander, Spain
University Medical Centre, Ljubljana, Slovenia
Center for Autoimmune Diseases, Sheba Medical Center, Tel-hashomer, Israel, Ramat Gan, Israel

Background/Purpose:

Primary Sjögren's syndrome (SS) is a chronic autoimmune disease primarily involving the exocrine glands. SS clinical picture ranges from exocrinopathy to systemic disease affecting the lung, kidney, liver, skin, musculockeletal and the nervous system. The morbidity of SS is mainly determined by extraglandular disease and increased prevalence of lymphoma1. Environmental and hormonal factors, such as vitamin-D may play a role in the pathogenic process and disease expression2. Thus, we aimed to evaluate the association between vitamin-D concentrations and the manifestations of SS.

Methods:

Vitamin-D levels were determined in 176 SS patients and 140 matched healthy volunteers utilizing the Liaison chemiluminescent immunoassays (DiaSorin-Italy), and correlated with clinical and serological manifestations of SS.

Results:

Vitamin-D levels were comparable between SS patients and control 20.5±10ng/ml and 21.6±10ng/ml respectively. Peripheral neuropathy or neuropathic pain were diagnosed in 23% of patients and associated with lower vitamin-D levels (18.6±5.5ng/ml vs. 22.6±8ng/ml (p=0.04)). Lymphoma was diagnosed in 4.3% of SS patients that showed vitamin-D deficiency 13.2±6.25ng/ml as compared with SS patients without lymphoma (22±8 ng/ml; p=0.03). Other clinical and serological manifestations did not correlate with vitamin-D status.

Conclusion:

In this study, low levels of Vitamin-D correlated with the presence of peripheral nerve involvement and lymphoma among SS patients. The link between vitamin-D neuropathy and lymphoma was reported in other conditions, and may support a role for vitamin-D in the pathogenesis of these processes as well as a beneficial effect for vitamin-D supplementation.

Tzioufas,  et al. Best Pract Res Clin Rheumatol. 2007

Shoenfeld,  etal. Nat Clin Pract Rheumatol. 2009

To cite this abstract, please use the following information:
Agmon-Levin, Nancy, Amital, Howard, Tzioufas, Athanasios G., Hoyos, Marcus López, Rozman, Blaz, Kivity, Shaye, et al; Low Levels of Vitamin-D are Associated with Neuropathy and Lymphoma Among Patients with Sjgren's Syndrome. [abstract]. Arthritis Rheum 2011;63 Suppl 10 :480
DOI:

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