Arthritis & Rheumatism, Volume 63,
November 2011 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Chicago, Illinois November 4-9, 2011.
Measuring S100A12 and Vascular Endothelial Growth Factor Can Differentiate Familial Mediterranean Fever and Early Onset Sarcoidosis From Systemic Juvenile Idiopathic Arthritis.
Yamasaki, Yuichi, Nerome, Yasuhito, Kubota, Tomohiro, Nonaka, Yukiko, Akaike, Harumi, Takezaki, Tomoko, Imanaka, Hiroyuki
A new consensus is now emerging that systemic juvenile idiopathic arthritis (sJIA) may be one of the autoinflammatory disease based on clinical and pathological mimicry. In fact, many children with autoinflammatory diseases such as familial Mediterranean fever (FMF) and early onset sarcoidosis (EOS) were initially diagnosed as sJIA1), a much more common febrile disease in children. Therefore, we examined serum levels of IL-6, S100 protein, and vascular endothelial growth factor (VEGF) so that measuring these biomarkers could be a screening test to differentiate these febrile conditions before undergoing a genetic testing.
Serum samples were obtained from 19 patients, 3 patients with FMF, 4 with EOS, and 12 with sJIA. Diagnosis of FMF and EOS were confirmed by gene examination. In these 19 patients, serum levels of IL-6, S100A12 and VEGF were examined by ELISA in both active (CRP>1.0 mg/dl) and inactive phase.
In active phase of patients, serum IL-6 level did differ in all disease groups. However, serum S100A12 levels were significantly high in both s-JIA (p<0.001) and FMF (p<0.001) patients compared with EOS patients (Figure 1). On the other hand, high levels of serum VEGF was observed only in s-JIA patients but not in FMF or EOS patients even though they were in active phase (p<0.001) (Figure 2).
In inactive phase of patients, no significant difference was observed in serum VEGF levels among the three disease groups. On the other hand, high levels of S100A12 were observed only in FMF patients who were non-treated or colchicine resistant.
Measuring serum S100A12 and VEGF levels at a time may be useful in differentiating FMF or EOS patients from patients clinically diagnosed as sJIA.
To cite this abstract, please use the following information:
Yamasaki, Yuichi, Nerome, Yasuhito, Kubota, Tomohiro, Nonaka, Yukiko, Akaike, Harumi, Takezaki, Tomoko, et al; Measuring S100A12 and Vascular Endothelial Growth Factor Can Differentiate Familial Mediterranean Fever and Early Onset Sarcoidosis From Systemic Juvenile Idiopathic Arthritis. [abstract]. Arthritis Rheum 2011;63 Suppl 10 :297