Arthritis & Rheumatism, Volume 63,
November 2011 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Chicago, Illinois November 4-9, 2011.


Juvenile Idiopathic Arthritis (Jia) Affected Sibling Pairs Present High Correlation for ANA and ILAR Category.

Filocamo,  Giovanni, Malattia,  Clara, Foeldvari,  Ivan, Stanevicha,  Valda, Nielsen,  Susan, Herlin,  Troels, Pruunsild,  Chris

Background/Purpose:

1) To investigate the clinical phenotypes and demographic characteristics of affected sibling pairs (ASPs) with juvenile idiopathic arthritis (JIA). 2) To provide an international resource of JIA DNA samples and a base of knowledge from which all genes contributing to the pathogenesis of JIA can be identified.

Methods:

This is a cross-sectional multicentric study in which all paediatric rheumatology centres belonging to the PRINTO network were asked to participate. PRINTO asked to provide demographic and clinical characteristics of the ASPs through electronic format and to collect DNA samples of JIA familiar cases, including all first degree relatives, deriving from the different centres.

Results:

Table 1. Demographic, clinical features and concordance between the sibs (2 or more within the same family) of the 106 individual affected sibpairs with JIA

 N (%)Mean (SD)MedianMinMaxConc.
Male25 (24)    0.24
Female81 (76)    0.79
Onset age –years 6.6 (4.4)6.20.516.3 
JIA category0 (0)    0.79
  Systemic arthritis61 (57.6)    /
  Oligoarthritis persistent18 (17)    0.85
  Oligoarthritis extended21 (19.8)    0.5
  Polyarthritis RF negative2 (1.9)    0.9
  Polyarthritis RF positive3 (2.8)    1
  Psoriatic arthritis0 (0)    0.67
  Enthesitis related arthritis1 (0.9)    /
  Other     0
Presence of ANA56 (56)    0.78
Absence of ANA44 (44)    0.68
Presence of iritis11 (10)    0.36
Absence of iritis86 (81)    0.9

Conclusion:

Preliminary results confirm the findings of earlier studies showing familial aggregation of clinical features among ASPs. In our study we observed high concordance of the presence of antinuclear antibodies (ANA), providing evidence for a genetic background in this disease. The DNA samples collected will allow to develop future studies on JIA.

To cite this abstract, please use the following information:
Filocamo, Giovanni, Malattia, Clara, Foeldvari, Ivan, Stanevicha, Valda, Nielsen, Susan, Herlin, Troels, et al; Juvenile Idiopathic Arthritis (Jia) Affected Sibling Pairs Present High Correlation for ANA and ILAR Category. [abstract]. Arthritis Rheum 2011;63 Suppl 10 :283
DOI:

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