Arthritis & Rheumatism, Volume 63,
November 2011 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Chicago, Illinois November 4-9, 2011.


Daily Intake of Skim Milk Powder Enriched with Glycomacropeptide and G600 Milk Fat Extract May Reduce Frequency of Gout Flares; Results From a Randomized, Controlled Trial.

Dalbeth1,  Nicola, Ames1,  Ruth, Gamble1,  Gregory, Horne1,  Anne, Wong1,  Sumwai, Kuhn-Sherlock2,  Barbara, MacGibbon2,  Alastair

University of Auckland, Auckland, New Zealand
Fonterra Research Centre, Palmerston North, New Zealand

Background/Purpose:

Dietary modification is frequently recommended as a strategy for prevention and treatment of gout. Longitudinal observational studies have shown a clear inverse relationship between low fat dairy intake and risk of developing gout. Previous laboratory studies have identified two dairy fractions, glycomacropeptide (GMP) and G600 milk fat extract (G600), with anti-inflammatory effects in models of acute gout. The aim of this proof-of-concept clinical trial was to test the hypothesis that daily intake of skim milk powder (SMP) enriched with GMP and G600 can prevent gout flares.

Methods:

This was a three month randomized, double blind controlled trial of milk products for prevention of gout flares. One hundred and twenty patients with recurrent gout flares were randomized to one of three arms; lactose powder control, SMP control, or SMP enriched with GMP and G600 (SMP/GMP/G600). Each intervention was a cream-coloured powder administered daily as a 250ml vanilla flavoured shake. The primary endpoint was change in the frequency of gout flares using a daily flare diary measured monthly for three months.

Results:

The frequency of gout flares reduced in all three groups over the three month study period compared with baseline. Over the three month study period there was a significantly greater reduction in gout flares in the SMP/GMP/G600 group (Figure, ANCOVA pgroup=0.039, Tukey post hoc test compared with lactose control p=0.042). Following treatment with SMP/GMP/G600 over the three month period, greater improvements were also observed compared with controls in pain and fractional excretion of uric acid, with a trend to greater improvement in tender joint count. Similar adverse event rates and discontinuation rates were observed between the three groups.

Figure. Primary endpoint: change in number of flares from baseline. ANCOVA analysis includes baseline flare frequency as a covariate. Data are presented as mean (95% CI).

Conclusion:

This is the first reported controlled trial of a dietary intervention in patients with gout, and suggests that SMP enriched with GMP and G600 may reduce the frequency of gout flares.

To cite this abstract, please use the following information:
Dalbeth, Nicola, Ames, Ruth, Gamble, Gregory, Horne, Anne, Wong, Sumwai, Kuhn-Sherlock, Barbara, et al; Daily Intake of Skim Milk Powder Enriched with Glycomacropeptide and G600 Milk Fat Extract May Reduce Frequency of Gout Flares; Results From a Randomized, Controlled Trial. [abstract]. Arthritis Rheum 2011;63 Suppl 10 :207
DOI:

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