Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Assessement of Physical and Mental Health Related Quality of Life, Disease Activity and Damage, Mental Health Status, and Cognitive Impairment in Chilean Women with Systemic Lupus Erythematosus.
Henriquez1, Carla, Flores2, Patricia, Marcela3, Babul, Calderon3, Jorge, Massardo3, Loreto
Psychosocial factors play an important role in the course of SLE. The aim of this study is to characterize the health-related quality of life (HRQoL) in Chilean women with SLE and their relationship with disease activity, and mental health status including cognitive function.
In this cross sectional study, 52 non selected Chilean women with SLE attending out patient clinic in Santiago were recruited in an 18 months period, they pay their medications from their own pocket. Completed the following measurements (i) HRQoL using the SF-12 questionnaire (assessing general health status [GHS], physical component summary [PCS] and mental component summary [MCS], (ii) SLE disease activity (SLEDAI-2K), (iii) damage (SLICC-ACR), (iv) 26 common mental disorders (CMD), according to the DSM-IV, using the Mini-International Neuropsychiatric Interview (MINI-plus), and (v) cognitive impairment (CI) in five domains of the Cambridge neurospychological auttomated test battery (CANTAB): memory, attention, executive function, work memory, and desicion making. CI was considered one or more test with a -1SD perfomance compared to 26 Chilean healthy controls paired by sex, age, and educational level.
Characteristics of participants: median age: 33 years (range= 1764); median disease duration from diagnosis: 2 years (0.126); stable couple: 37%; active working/students: 65%; median years of formal education: 14 (919); median SLEDAI-2K: 7 (025); median SLICC: 0 (04). At least one CMD was present in 27 (53%), 14 (28%) major depressive episode (MDE), 15 (30%) at suicidal risk (29%): four were at high level, 5 at moderate and 6 at low risk.
Patients considered their GHS as poor (16%), regular (47%), good or very good (37%). PCS median was 39.1 (24.2857.58) and MCS median was 35.8 (16.259.4). PCS and MCS inversely correlated with disease activity (Spearman Rho=-0.327; P= 0.023; R=-0.349; P= 0.015, respectively). Accrued disease damage inversely correlated with PCS (R=-0.347; P=0.015). Patients affected with MDE had lower PCS and MCS than those without MDE (P=0.045; P=0.00, respectively). Disease activity was similar in both groups. CI in two domains attention and executive function were found in 22 (42%) not associated with MDE (P=NS).
This survey found 53% of presence of CMD and 28% of MDE. These frequencies are considerably higher than those previously reported in the general population living in Santiago, Chile (18% and 8%, respectively), moreover the number of patients at suicidal risk is high (<0.1%). HRQoL components PCS and MCS were > 1 SD lower compared to Chilean general population (score 50 ± 10). Disease activity related to a worse HRQoL in both components while accrued damage associated only with lower PCS score. MDE affected both components of HRQoL. CI in attention and executive function is a relevant problem in this study. Overall 63% of patients considered their general health status as bad or regular implying a challenge for a the rheumatology staff to provide a better health care involving transdisciplinary teamwork.
Supported by FONDECYT grant number 1085283
To cite this abstract, please use the following information:
Henriquez, Carla, Flores, Patricia, Marcela, Babul, Calderon, Jorge, Massardo, Loreto; Assessement of Physical and Mental Health Related Quality of Life, Disease Activity and Damage, Mental Health Status, and Cognitive Impairment in Chilean Women with Systemic Lupus Erythematosus. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :2070