Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.


Accumulation of Traditional Risk Factors for Coronary Heart Disease in Patients with Systemic Lupus Erythematosus.

Telles2,  Rosa W., Lanna2,  Cristina C. D., Simil1,  Fabricia F., Machado1,  Luana G., Sousa1,  Fabiana L., Rodrigues2,  Luciana A., Ribeiro3,  Antonio L.

Hospital das Clinicas
School of Medicine
School of Medicine-Universidade Federal de Minas Gerias-Brazil

Objective:

to examine the accumulation of traditional risk factors for Coronary Heart Disease (CHD) in patients with SLE.

Patients and Methods:

157 patients included in a prospective study of atherosclerosis in lupus patients were followed during 39(37–42) months. Traditional risk factors for CHD were collected at entry (T0), trough out the follow up (considered positive when the risk factors were identified in two different occasions for a period >=1 year) and at the last study visit (T1). The hypothesis of risk factors accumulation was investigated comparing the prevalence of those factors between T0 and T1 using either McNemar or Wilcoxon tests. The annual mean incidence of the risk factors was determined.

Results:

median (IR) age at entry and age at lupus diagnosis of the 157 patients were 38(29–46) years and 27.3(21.5–34.7) years, respectively (96.2%: female gender; 75.8%: non-white). Median (IR) duration of lupus was 7.7(4.3–11.4) years. The prevalence of the following traditional risk factors increased during study interval (T0x T1): positive family history for coronary heart disease (12.7%x 15.9%; p=0.025), postmenopausal status (38.2%x 45.2%; p=0.001), hypertension (46.5%x 55.4%; p=0.003), obesity (19.7%x 29.3%; p=0.006) and abdominal obesity (42%x 60.5%; p<0.001). The number of current smokers did not differ (14%x 12.1%; p=0.250). Although the prevalence of LDL>=130mg/dl (16,6%x 22,9%; p=0,036) and the total cholesterol>=200mg/dl (19,7%x 28,7%; p=0,024) increased, the prevalence of HDL<40mg/dl did not change (26,8%x 20,4%; p=0,268). The number of traditional risk factors (age and sex, hypertension, diabetes mellitus, dyslipidemia, hypertiglyceridemia, family history for CHD and smoking habit) per patient also increased during the study interval [1(0–2) x 2(1–3); p=0.015]. The annual mean incidence of the traditional risk factors were: hypertension 4%, diabetes mellitus 0.8%, dyslipidemia 10%, triglycerides>=150mg/dl 5.1%, obesity (BMI>30kg/m2) 5.1% and abdominal obesity (abdominal circumference >102cm in men and >88cm in women) 11.5%.

Conclusion:

the prevalence of traditional risk factors for CHD increased in a short-period in young patients with SLE. Some of these risk factors have already been associated with clinical and subclinical atherosclerosis in lupus. Lupus patients should be monitored for cardiovascular risk factors in a regular basis and appropriate treatment instituted.

To cite this abstract, please use the following information:
Telles, Rosa W., Lanna, Cristina C. D., Simil, Fabricia F., Machado, Luana G., Sousa, Fabiana L., Rodrigues, Luciana A., et al; Accumulation of Traditional Risk Factors for Coronary Heart Disease in Patients with Systemic Lupus Erythematosus. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1842
DOI: 10.1002/art.29607

Abstract Supplement

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