Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Contribution of the Rheumatoid Arthritis Impact of Disease (RAID) on Disease Activity in Rheumatoid Arthritis (RA).
Uhlig1, Till, Heiberg3, Turid, Austad2, Cathrine, Kvien1, Tore K.
The RAID score is a new patient reported outcome developed through a EULAR task force (1). The OMERACT (Outcome Measures in Rheumatoid Arthritis Clinical Trials) group recently put on its research agenda a need to explore how RAID relates to disease activity in RA. Currently, patient global assessment of disease activity (PatGlob) is the patient reported variable included in DAS28.
To provide data on validity of RAID and contribution to assessment of disease activity in a large data set from a population based RA registry 2009 (ORAR).
In a population based RA registry in Oslo, Norway, 868 patients aged 2079 years (mean (SD) age 59.9 (12.3) years, disease duration 13.0 (10.8) years, 77.1% females, 57.0 % RF+ or CCP+) responded in 2009 to a mailed questionnaire (response rate 60.6%). RAID score (010) is calculated from seven domains, perceived by patients to be particularly important: pain, functional disability, fatigue, sleep problems, emotional and physical well-being, coping. The Rheumatoid Arthritis Disease Activity Index (010) was used to assess disease activity. Other patient reported outcomes separately assessed included pain, fatigue and PatGlob on 100 mm visual analogue scales, modified HAQ, SF-36 with physical (PCS) and mental component summary (MCS) (low scores=poor health), and SF-6D derived utility.
Pearson correlation coefficients are reported between RAID and measures of disease activity. We further used linear regression analysis to calculate the explained variance of RAID and of PatGlob for disease activity in RA.
RAID was mean 3.35 (SD 2.16), disease activity (RAID) was 3.20 (SD 1.71) and both were strongly correlated (r=0.82). RAID was also highly or substantially correlated to other core measures of disease activity: pain (r=0.81), patients global (r=0.84), for physical function HAQ (r=0.67) and PCS (r=0.72), and also to fatigue (r=0.68), mental health (MCS) (r=0.52) and SF-6D derived utility (r=0.78).
RAID explained 67% of the variance in disease activity, PatGlob explained 71%, and both together explained 77%.
RAID was highly and substantially related to core measures and to an index (RADAI) of disease activity. PatGlob explained only slightly more than RAID of the variation in disease activity. These results support that RAID as a global composite of disease is closely related to disease activity in RA.
To cite this abstract, please use the following information:
Uhlig, Till, Heiberg, Turid, Austad, Cathrine, Kvien, Tore K.; Contribution of the Rheumatoid Arthritis Impact of Disease (RAID) on Disease Activity in Rheumatoid Arthritis (RA). [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1750