Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Longitudinal Study on Growth Failure and Height Deflection in Juvenile Systemic Lupus Erythematosus (JSLE): The Result of a Prospective Multicentre PRINTO Study.
Rygg3, Marite, Pistorio3, Angela, Ravelli3, Angelo, Maghnie3, Mohamad, Iorgi3, Natascia Di, Demirkaya3, Erkan, Pasic3, Srdjan
Growth failure is a unique feature of JSLE, caused by long-term disease activity, side effects of drugs, and/or co-morbid conditions.
The goal of the study was to obtain longitudinal data on growth in a large-scale, multi-national cohort of patients with JSLE followed for 26 months.
Materials and Methods:
This prospective, multi-centric study on JSLE was carried out in 39 countries from Northern and Southern Europe, Latin America, US and Asia between 2001 and 2004. Patients seen at the participating centers with diagnosis of JSLE, at active phase, and age younger than 18 years at enrollment were included.
Data was collected from 557 patients with JSLE. There was a significant reduction in parent-adjusted height z score with time in females and males (p<0.0001) with a significant gender difference (p<0.0001), male height being most affected. Median BMI z score peaked at 6 months and was still significantly above baseline after 26 months (p<0.01) with no gender difference. Standardized height reduction was inversely related to age at disease onset in females, especially pronounced at onset age <8 years. Females with onset age <12 years had a median parent-adjusted height z score of -0.87 with no catch-up growth. At the end of the study, growth failure was seen in 14.7% of the females and 24.5% of the males. Height deflection (less than-0.25/year) was found in 20.7% of the females and 45.5% of the males.
The longitudinal effect on height is modest in JSLE females with age at onset >=12 years. In spite of all our knowledge and careful treatment, females <12 years at onset and males are still at risk of experiencing a considerable height loss during the course of the disease.
To cite this abstract, please use the following information:
Rygg, Marite, Pistorio, Angela, Ravelli, Angelo, Maghnie, Mohamad, Iorgi, Natascia Di, Demirkaya, Erkan, et al; Longitudinal Study on Growth Failure and Height Deflection in Juvenile Systemic Lupus Erythematosus (JSLE): The Result of a Prospective Multicentre PRINTO Study. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1684