Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Ultrasound Bone ErosionsTheir Morphological Basis Obtained by High-Resolution Micro-Computed Tomography Imaging.
Finzel2, Stephanie, Ohrndorf1, Sarah, Englbrecht2, Matthias, Stach2, Christian M., Messerschmidt1, Janin, Schett3, Georg, Backhaus4, Marina
Charite University Hospital, Berlin, Germany
Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany
Friedrich Alexander Univ, Erlangen, Germany
University Medicine Berlin: Campus Charité Mitte, Berlin, Germany
To validate, whether bony lesions appearing in high-resolution ultrasound (HRUS) are true bone erosions.
In total, 26 individuals (14 with rheumatoid and 6 with psoriatic arthritis as well as 6 healthy controls) were assessed for bone erosions at the radial, palmar and dorsal side of the MCP2 and the palmar and dorsal sides of the MCP3 and MCP4 joint. All patients received a HRUS and for validation of results a micro-computed tomography scan (mCT). The prevalence (0/1) and severity of bone erosions obtained in HR US and mCT were recorded and compared.
Overall there was a good correlation between the severity of US erosions and mCT erosions (r= 0.463, p < 0.0001).
False-negative (US 1/ mCT 0) results were obtained in only 10% of the joint regions and were mostly due to small erosive lesions at the dorsal sides of the MCP joints. False-positive results were more frequent (28%) and primarily based on vascular bone channels at the palmar sides of the MCP joints as well pseudo-erosions created by osteophytes.
These data show that the majority of erosion in the US was indeed based on true bone erosions with a cortical break. The sensitivity of US for detecting bone erosions was high and there was a good correlation between the severity of bone erosions in the US and the mCT imaging. Specificity of US for bone erosions was substantially lower, suggesting that smaller US lesions do not always refer to true breaks in the cortical bone surface.
To cite this abstract, please use the following information:
Finzel, Stephanie, Ohrndorf, Sarah, Englbrecht, Matthias, Stach, Christian M., Messerschmidt, Janin, Schett, Georg, et al; Ultrasound Bone ErosionsTheir Morphological Basis Obtained by High-Resolution Micro-Computed Tomography Imaging. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1634