Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
The Power Doppler Ultrasonography Score from 24 Synovial Sites or 6 Simplified Synovial Sites, Including the Metacarpophalangeal (MCP) Joints, Reflects Well the Clinical Disease Activity and Serum Biomarkers in Patients with Rheumatoid Arthritis.
Kawakami1, Atsushi, Kawashiri1, Shin-ya, Iwamoto1, Naoki, Tamai1, Mami, Nakamura1, Hideki, Kita1, Junko, Okada1, Akitomo
Purpose of Study:
We evaluated the significance of the power Doppler ultrasonography (PDUS) score by comparing it with serum biomarkers and clinical disease activity.
We measured the PDUS scores of 24 synovial sites in 12 joints in 22 RA patients. For convenience, the PDUS scores of 6 synovial sites in 6 joints were also examined. Both PDUS scores included the metacarpophalangeal (MCP) joints. Each joint was scored for a power Doppler (PD) signal on a scale from 0 to 3. The PDUS scores are the sums of the PD signal scores for the 24 synovial sites or the 6 synovial sites. On the same day, serum variables as well as clinical disease activity were evaluated. Serum variables included vascular endothelial growth factor (VEGF), matrix metalloproteinase-3 (MMP-3), MMP-9 and tissue inhibitor of metalloproteinases-1 (TIMP-1). The clinical disease activity included the disease activity score of 28 joints (DAS28), the simplified disease activity score (SDAI) and the clinical disease activity score (CDAI).
The PDUS scores from the 24 joint sites were significantly positively correlated with tender joints counts, swollen joint counts, DAS28, SDAI, CDAI and serum biomarkers including MMP-3, VEGF and TIMP-1, whereas it did not correlate with MMP-9. Accordingly, the PDUS scores from the 6 synovial sites greatly correlated with those from the 24 joint sites. Clinical disease activities as well as serum variables were also clearly correlated with the PDUS scores from the 6 synovial sites.
The standard as well as the simplified PDUS scores well reflected clinical disease activity and serum variables, including angiogenic factors. Our data reaffirm the utility of ultrasonography for monitoring disease activity in patients with RA.
To cite this abstract, please use the following information:
Kawakami, Atsushi, Kawashiri, Shin-ya, Iwamoto, Naoki, Tamai, Mami, Nakamura, Hideki, Kita, Junko, et al; The Power Doppler Ultrasonography Score from 24 Synovial Sites or 6 Simplified Synovial Sites, Including the Metacarpophalangeal (MCP) Joints, Reflects Well the Clinical Disease Activity and Serum Biomarkers in Patients with Rheumatoid Arthritis. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1632