Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.


Fragility Fractures in Brazilian Community-Dwelling Elderly: Prevalence and Risk Factors.

B. Lopes,  Jaqueline, P. Figueiredo,  Camille, Takayama,  Liliam, F. Caparbo,  Valeria, M. R. Pereira,  Rosa

Purpose:

Estimate the prevalence of fragility fractures and investigate factors associated with this condition in Brazilian community-dwelling elderly.

Methods:

1075 elderly subjects (659 women/416 men) from São Paulo, Brazil were evaluated using specific questionnaire including risk factors for osteoporotic fractures. Fragility fractures were defined as those resulting of a fall from standing height or less after 50 years of age at sites characteristic of bone fragility. Traumatic fractures and those occurring at the face, skull, ankle, elbow and finger were not considered. Anthropometric data was obtained by physical examination and body mass index (BMI) was calculated. Bone mineral density (BMD) was measured by DXA in hip and lumbar spine. Laboratory tests were also determined.

Results:

The prevalence of fragility fractures was of 11.9% (127) and the main fracture sites were forearm (50.4%), humerus (19.7%), femur (11.2%) and ribs (8.7%). Women had higher prevalence (15.3%; 95%CI 12.6–18.1) than men (6.5%; 95%CI 4.1–8.9) (P<0.001). In women, the main factors associated with fractures were Caucasian race (OR=1.7; 95%CI 1.1–2.8; P=0.027), BMI (OR=0.9; 95%CI 0.89–0.98; P=0.002) and femoral neck T-score (OR=0.7; 95%CI 0.5–0.9; P<0.001). After adjustment for these significant variables, the logistic-regression analyses revealed that Caucasian race (OR=1.7, 95%CI 1.03–2.7 P=0.038) and femoral neck T-score (OR=0.7, 95%CI 0.51–0.86; P=0.002) remains a significant factor for fragility fractures in women. In men, the main factors associated with fragility fractures were current smoking (OR=3.2; 95% CI 1.4–7.6; P=0.007), diabetes mellitus (OR=3.1; 95%CI 1.3–7.1; P=0.008), chronic faller (OR=2.9; 95%CI 1.1–7.6; P=0.033) and femoral neck T-score (OR=0.4, 95%CI 0.2–0.6; P<0.001). The logistic-regression analyses revealed that current smoking (OR=2.5, 95% CI 1.2–6.2; P=0.048), diabetes mellitus (OR=4.5; 95%CI 1.8–11.1; P=0.001) and femoral neck T-score (OR=0.4, 95%CI 0.2–0.6; P<0.001) were independent factors in predicting fragility fractures in men.

Conclusions:

Our results suggest that fragility fractures are common in Brazilian community-dwelling elderly, and a low hip BMD was an important risk factor for this condition in both genders. In men, diabetes and smoking are also related to this complication. The identification of these factors may improve the prediction of fracture risk and enhance the evaluation of patients with osteoporosis.

To cite this abstract, please use the following information:
B. Lopes, Jaqueline, P. Figueiredo, Camille, Takayama, Liliam, F. Caparbo, Valeria, M. R. Pereira, Rosa; Fragility Fractures in Brazilian Community-Dwelling Elderly: Prevalence and Risk Factors. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1546
DOI: 10.1002/art.29312

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