Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Erectile Dysfunction Is Associated with Gout in the Campaign Against Cancer and Heart Disease (CLUE II).
W. Maynard, Janet, A. McAdams, Mara, N. Baer, Alan, Hoffman-Bolton, Judith, C. Gelber, Allan, Coresh, Josef
Erectile dysfunction (ED) is related to a variety of chronic medical conditions, including hypertension, obesity, and cardiovascular disease. We sought to identify whether gout was associated with ED independent of risk factors for cardiovascular disease in a community-based setting.
The CLUE II cohort consists of individuals, aged 13 to 87 years, who resided within or surrounding Washington County, Maryland. All participants received follow-up questionnaires (1996, 1998, 2000, 2003, and 2007). At baseline in 1989, participants were asked to self-report gender, race, age, and height. On the 2007 follow-up questionnaire, participants self-reported weight and a physician or health professional diagnosis of gout, ED, diabetes, and hypertension. This study was restricted to CLUE II participants who responded to the 2007 questionnaire (7,142) and were male. We assessed whether having gout was associated with ED. The distributions of variables among the men with gout versus those who did not have gout were compared using chi-squared or t-tests, as appropriate. We assessed the relationship between gout and ED with odds ratios from logistic regression.
Of the 2,605 male participants responding to the 2007 questionnaire, 256 (9.8%) had gout and 779 (29.9%) had ED. A significantly greater proportion of participants with gout had ED (102, 39.8%) compared to participants without gout (677, 28.8%), p<0.001. The mean age of participants with gout was significantly greater than those without gout (68.7±11.3 years vs. 65.0 ±12.3 years, p<0.001). A significantly greater proportion of participants with gout were obese (BMI >= 30 kg/m2) (47.9%) compared to those without gout (32.1%), p<0.001. Similarly, a significantly greater portion of participants with gout were hypertensive (72.0%) compared to those without gout (47.8%), p<0.001. A greater proportion of gout participants were diabetic (15.2%) than participants without gout (8.6%), p<0.001. There was a statistically significant association between gout and ED, even after adjustment for age (Table). However, this association was not observed after adjustment for hypertension, obesity, and diabetes.
Table. Association between Gout and Erectile Dysfunction.
|ED and Gout OR (95% CI)|
|Model 1: Unadjusted||1.64 (1.25, 2.13)|
|Model 2: Age||1.38 (1.05, 1.83)|
|Model 3: Model 2 + hypertension||1.24 (0.94, 1.64)|
|Model 4: Model 3 + obesity||1.19 (0.90, 1.59)|
|Model 5: Model 4 + diabetes||1.15 (0.85, 1.53)|
|Significant values (p <0.05) are bold.|
|Abbreviations: OR (odds ratio), CI (confidence interval)|
In a community-based cohort we found that men with gout are more likely to have ED than men without gout, even after adjustment for age. However, this relationship may be mediated by obesity, diabetes, and hypertension, which are known risk factors for ED. Potential causal mechanisms need to be investigated, but even in their absence, the association suggests that physicians should explore this common treatable condition with their gout patients.
To cite this abstract, please use the following information:
W. Maynard, Janet, A. McAdams, Mara, N. Baer, Alan, Hoffman-Bolton, Judith, C. Gelber, Allan, Coresh, Josef; Erectile Dysfunction Is Associated with Gout in the Campaign Against Cancer and Heart Disease (CLUE II). [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1544