Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Cluster Analysis of Vascular Involvement in Takayasu Arteritis: Extension of the Lesions Is Contiguous in the Aorta and Symmetric in Paired Arterial Beds.
Arnaud1, Laurent, Haroche1, Julien, Toledano2, Dan, Cacoub1, Patrice, Costedoat-Chalumeau1, Nathalie, Huong-Boutin1, Du Le Thi, Cluzel2, Philippe
Department of Internal Medicine, Groupe Hospitalier Pitié-Salpêtriere, UPMC Univ Paris 6, AP-HP, 4783 bd de l'Hôpital, Paris, France
Department of Radiology, Groupe Hospitalier Pitié-Salpêtrière, UPMC Univ Paris 6, AP-HP, 4783 bd de l'Hôpital, 75013, Paris, France.
The determinants of vessel targeting are largely unknown in vasculitides. The aim of this study was to identify patterns of vascular involvement in Takayasu's arteritis (TA), using cluster analysis.
Peripheral vascular Doppler, CT angiography and angio-MRI data of 82 patients with TA (ACR criteria) were studied between Jan. 1995 and May 2006. Cross-involvement between 24 main arteries were assessed using the Phi correlation coefficient. Patterns of vascular involvement were identified using hierarchical cluster analysis.
Data were obtained from 68 women (82.9%) and 14 men (17.1%). The median duration of follow-up was 5.1 years (range: 1 month to 30 years).
For 16 (80%) of 20 paired arteries, the highest correlation of involvement was observed with the contralateral artery (r=0.31 to 0.66). Conversely, the involvement of the abdominal aorta best correlated with that of the thoracic descending aorta (r=0.38, p=0.0005), and this latter best correlated with the aortic arch (r=0.44, p<0.0001). This suggests contiguous extension in the aorta.
Cluster analysis visually confirmed that all paired arterial beds, but the internal and external carotid arteries, clustered with their contralateral counterpart, and that the aortic arch, the descending thoracic aorta and the abdominal aorta clustered together.
Our study reveals that TA lesions mostly develop in a symmetric manner in paired vascular territories and that disease extension is contiguous in the aorta. This may prove useful for improving the radiological follow-up of patients with TA, and for providing a pattern for further investigations focusing on the mechanisms of vessel-specificity in vasculitides.
To cite this abstract, please use the following information:
Arnaud, Laurent, Haroche, Julien, Toledano, Dan, Cacoub, Patrice, Costedoat-Chalumeau, Nathalie, Huong-Boutin, Du Le Thi, et al; Cluster Analysis of Vascular Involvement in Takayasu Arteritis: Extension of the Lesions Is Contiguous in the Aorta and Symmetric in Paired Arterial Beds. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1287