Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Clinical Features of Behet's Disease with Vascular Involvement.
Kikuchi2, Hirotoshi, Asako1, Kurumi, Takayama1, Maki, Kono1, Hajime, Hirohata4, Shunsei, Ono3, Yasuo
Department of Internal Medicine, Teikyo University School of Medicine
Department of Microbiology and Immunology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan
Department of Microbiology and Immunology, Teikyo University School of Medicine
Department of Rheumatology and Infectious Disease, Kitasato University School of Medicine, Kanagawa, Japan
Behçet's disease (BD) is characterized by recurrent oral aphthous stomatitis, ocular involvement, genital ulcer, and skin lesions. Although one of the serious manifestations of BD is vascular involvement (VBD), its pathogenesis remains unclear. The current studies were therefore undertaken to delineate the clinical characteristics of VBD and to explore its pathological features.
Patients and Methods:
The clinical records of 277 patients who satisfied the 1990 international criteria for Behçet's disease and were hospitalized in Department of Internal Medicine, Teikyo University School of Medicine, from January 1989 to December 2009 were reviewed.
Forty two patients (25 males and 17 females) had been diagnosed with VBD. The mean age of BD onset was 35.6±11.8 years (mean±SD), and the mean delay for the development of VBD was 5.8 years. The frequency of HLA-B51, HLA-A26, pathergy test and complete type was 34.4%, 13.3%, 42.9% and 38.1%, respectively. The vessels involved were as follows: the most frequent venous lesion was deep vein thrombophlebitis (42.9%), followed by deep vein thrombosis (40.5%), superior vena cava syndrome (9.5%), and inferior vena cava obstruction (4.8%) and frequent arterial lesions were aortic aneurysm (11.9%), pulmonary aneurysm (9.5%), femoral artery stenosis (7.1%), and subclavian arterial stenosis (4.8%).
Seven patients suffered from both venous and arterial lesions. Two patients died because of hemoptysis from pulmonary arterial aneurysms. One of 7 patients who were complicated with pulmonary embolism died.
These results indicate that the frequency of vascular manifestations tended to be higher for venous lesions (81.0%) compared with arterial lesions (28.6%). In particular, the main complication associated with death was pulmonary vessel involvement.
To cite this abstract, please use the following information:
Kikuchi, Hirotoshi, Asako, Kurumi, Takayama, Maki, Kono, Hajime, Hirohata, Shunsei, Ono, Yasuo; Clinical Features of Behet's Disease with Vascular Involvement. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1285