Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.


Association of Gastrointestinal Involvement and Depressive Symptoms in Patients with Systemic Sclerosis.

Bodukam1,  Vijay, Hays2,  Ron D., Maranian2,  Paul, Furst2,  Daniel E., Seibold3,  James R., Impens4,  Ann, Mayes5,  Maureen D.

Interfaith Medical Center, Brooklyn, Los Angeles, CA
UCLA
Univ of Connecticut
University of MIchigan
University of Texas Houston

Background:

Systemic sclerosis-associated gastrointestinal tract involvement (SSc-GIT) is an important predictor of depressive symptoms. UCLA Scleroderma Clinical trial Consortium Gastrointestinal tract 2.0 (UCLA SCTC GIT 2.0) is a 34 item instrument that captures GIT symptom severity and impact on quality of life. This instrument is feasible, reliable and valid. It has seven scales—reflux, distension/bloating, diarrhea, fecal soilage, constipation, emotional well-being and social functioning and a total GIT score.

Objective:

To assess 1) whether there is an association between depressed mood with GI symptoms as assessed by the UCLA SCTC GIT 2.0 instrument, and 2) to explore which GI specific symptom scales are associated with depressed mood in patients with SSc.

Methods:

152 patients with SSc completed the UCLA SCTC GIT 2.0 and the Center for Epidemiologic Studies Short Depression scale (CES-D 10; 0–30). Patients were divided into depressed (CES-D >= 10) or non-depressed group (CES-D < 10) and compared using t-test or Chi-Square test. Multiple linear regression was used to determine associations between GI scales and depressed mood (CES-D).

Results:

Study participants were 84% female, 78% Caucasian and 40% had depressed mood (CES-D10 >= 10). Patients with depressed mood had statistically worse GI scale scores (except fecal soilage) and worse total GIT score (P<0.05). In the multivariable model, reflux and constipation scales were independently associated with worse CES-D scores (P=0.01 to 0.06)

Conclusion:

SSc-GIT involvement is associated with depressed mood. Reflux and constipation scales of UCLA-SCTC GIT 2.0 were independently associated with CES-D. Future studies should assess if treatment of GIT symptoms will improve depressed mood in patients with SSc-GIT.

Figure. UCLA SCTC GIT 2.0 scale scores in patients with and without depressed mood.

To cite this abstract, please use the following information:
Bodukam, Vijay, Hays, Ron D., Maranian, Paul, Furst, Daniel E., Seibold, James R., Impens, Ann, et al; Association of Gastrointestinal Involvement and Depressive Symptoms in Patients with Systemic Sclerosis. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1205
DOI: 10.1002/art.28971

Abstract Supplement

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