Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Fatigue in Inflammatory Arthritis: Clinical Characteristics, and Contributory Factors Following 6-Months of Anti-TNF Therapy.
Minnock1, Patricia, Bresnihan3, Barry, McKee2, Gabrielle, FitzGerald3, Oliver, Veale3, Douglas
The unique contribution of fatigue to the assessment of patients with inflammatory arthritis has been demonstrated. The aim of this study was to elucidate the clinical characteristics of, and contributory factors to, fatigue in patients with inflammatory arthritis prescribed anti-TNF therapy.
Patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) commencing anti-TNF therapy underwent standard clinical assessment of disease activity and fatigue at baseline, 3-months and 6-months. Fatigue was measured using the multidimensional assessment of fatigue scales (MAF), validated for use in RA. The MAF comprises 16 questions concerning the quality, degree, distress, impact and timing of fatigue, compiled to give a final score of 150; a low score corresponds to a low level of fatigue. The clinical characteristics of, and the relationship between fatigue and 6 core outcome measures was evaluated.
One-hundred thirty seven patients were evaluated (RA, 93; PsA, 44). Mean age (SD) years, and disease duration at inclusion were 52 (13), 12 (11), respectively. Both fatigue and the core outcome measures demonstrated a significant improvement over the 3-timepoints. Mean (SD) MAF levels were 27.5 (11.1) at baseline, 18.07 (12.1) at 3-months and 19.04 (11.8) at 6-months (p<0.001). Mean (SD) SJC were 7.6 (6.2) at baseline, 2.2 (3.1) at 3-months, and 1.6 (2.6) at 6-months (p<0.001). Mean (SD) TJC were 9.4 (7.8) at baseline, 2.9 (4.5) at 3-months and 2.6 (5.1) at 6-months (p<0.000). Mean (SD) Pain were 5.4 (2.1) at baseline, 3.5 (2.3) at 3-months and 3.5 (2.0) at 6-months (p<0.000). Mean (SD) GH were 5.9 (2.2) at baseline, 3.7 (2.4) at 3-months and 3.8 (2.1) at 6-months (p<0.000). Mean (SD) HAQ were 2.5 (1.0) at baseline, 0.78 (0.80) at 3-months and 0.75 (0.66) at 6-months (p<0.003). Mean (SD) CRP were 20.6 (25.4) at baseline, 71.0 (7.8) at 3-months and 8.8 (15.3) at 6-months (p<0.000). Tests were significant at the 0.01 level (2-tailed). Fatigue was moderately correlated with Pain 0.423 (0.578), (0.482); GH 0.425 (0.578), (0.500) and HAQ 0.470, (0.345), (0.344) (p<0.001) at baseline, at 3-months, and at 6-months, respectively. The strongest correlation found between fatigue and SJC (0.358) and TJC (0.409) were at 3-months only. All correlations were significant at the 0.01 level. The only variable that made a significant contribution to explanation of fatigue at 6-months was GH (R2=35%), F=0.65; p= 0.000; Beta=0.345). At 6-months the relative independent variance in fatigue was 17%, greater than most of all the core clinical measures: HAQ 17%, SJC 16%, TJC 15%, CRP 14%, Pain 10%, GH, 10%.
Fatigue provides unique information in the assessment of outcome for patients with inflammatory arthritis which warrants further in-depth examination.
To cite this abstract, please use the following information:
Minnock, Patricia, Bresnihan, Barry, McKee, Gabrielle, FitzGerald, Oliver, Veale, Douglas; Fatigue in Inflammatory Arthritis: Clinical Characteristics, and Contributory Factors Following 6-Months of Anti-TNF Therapy. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :1032