Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.


National Registry of Paget Disease of Bone.

Loza,  Estibaliz, Guanabens,  Nuria, Jesus Garcia de Yebenes,  Maria, Morales,  Antonio, Del Pino,  Javier, Torrijos,  Antonio, Garrido,  Jesus

Objective:

a) To identify and establish a national registry of patients with Paget disease of bone (PDB); b) To describe patient's demographic, clinical, environmental and familiar characteristics.

Methods:

A registry-based cross-sectional study was performed. It started with a prevalence study (2006–2007) in which stratified samples throughout Spain of abdominal radiographs, of subjects aged >=55 years, from stored consecutive digitalized films in selected hospitals were obtained. Radiographs including all lumbar vertebrae, pelvis, sacrum and femoral heads were examined for the diagnosis of PDB, according to standardized criteria. Afterwards, experts on Paget disease were invited to include patients in the registry from their clinics (apart from those identified in the prevalence study). Data were recorded following a standardized electronic form: demographics (age, sex); clinical (diagnosis date, age at the disease onset, symptoms and treatment); quality of life [EuroQol 5D, visual analog scale (VAS) of pain]; environmental factors (infections, place of birth, birth weight, number of brothers/sisters and position, measles virus infection, contacts with domestics animals, non pasteurized milk intake, home characteristics during childhood, >= 1 year-places of residence, work status); familiar (positive familiar history and place of birth of positive cases, number of children and their measles exposure/vaccination). A descriptive study was performed.

Results:

The crude prevalence of PDB was 1% (95% Confidence Interval (CI): 0.7–1.3) in patients aged >=55 years, and the estimated prevalence ranged from 1.1% (95%CI: 0.8–1.4) to 1.6% (95%CI: 1.1–2.1) when a reported pelvic involvement in 60–90% of PDB patients was considered. A total of 602 patients with PDB from 24 hospitals were included in the registry. We found more men (55%), with a mean age of 62 years ± 11 years. More than 80% had followed any treatment, 55% risedronate, 32% calcitonin, and almost 50%>=2 drugs. The mean VAS pain score was 65 ± 21. The dimension which showed the worst score was anxiety/depression (64% reported moderate or severe limitations), followed by mobility (47%), and just 24% reported moderate or severe limitations in usual activities. Most of patients (99%) were born in Spain: Barcelona (11%), Ávila (10%), Toledo (7%) and Salamanca (5%). Measles infection was reported in 65%, and 80% had had contacts with animals: dogs (70%), cats (48%), and birds (38%). Non pasteurized milk intake was observed in 75% of patients and 53% were retired. A positive familiar history was registered in 14%, especially in Ávila and Salamanca, and PBD was identified in 1.5% of patient's children.

Conclusions:

The National Registry of PDB includes 602 patients with PDB. Up to 14% have a positive familiar history, 80% contacts with domestic animals, and most of them had been on pharmacological treatment.

To cite this abstract, please use the following information:
Loza, Estibaliz, Guanabens, Nuria, Jesus Garcia de Yebenes, Maria, Morales, Antonio, Del Pino, Javier, Torrijos, Antonio, et al; National Registry of Paget Disease of Bone. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :975
DOI: 10.1002/art.28742

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