Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Correlation between Bone Mineral Density and Urine Carboxyl Terminal of Collagen Type (CTX) in Premenopausal Fibromyalgia Patients.
Alsalawy3, Alaa, Kamel2, Mohammed M., Eweis1, Ibrahim
The aim of the study was to compare Bone mineral Density (BMD), Serum Osteocalcin (OC), and Urine Carboxyl terminal of collagen type I(CTX) of premenopausal patients suffering from fibromyalgia(FMS), to that of healthy premenopausal females. Then to determine the relationship between (BMD), urine( CTX), and the development of rapid bone loss and early osteoporosis among premenopausal fibromyalgic patients.
Subjects and Method:
Thirty-one premenopausal patients with fibromyalgia and thirty age matched healthy females subjects as a control group were included in this study. Serum osteocalcin and urine CTX were measured using ELISA technique (Enzyme Linked Immune Sorbent assay) in all cases, BMD was measured in femoral neck and lumber spine by using X- ray absorptiometry. Statistical analysis were done using SPSS virgin 15. Student's unpaired (t)test and pearson's correlation analysis were performed to assess the correlation between BMD and urine CTX.
BMD of lumber and femoral neck were significantly lower in fibromyalgic patients compared to the healthy females (p<0.001). Serum Osteocalcin were lower in fibromyalgic patients with no significant difference compared to healthy females. There were a significant negative correlation between urine CTX and BMD of lumber spine and femoral neck in fibromyalgic patients.
The results of this study indicate that the fibromyalgic premenopausal patients are highly susceptible to develop osteopenia and early osteoporosis comapred to normal healthy subjects. We recommend to measure BMD of all fibromyalgia patients especially those with high level of urine CTX.
To cite this abstract, please use the following information:
Alsalawy, Alaa, Kamel, Mohammed M., Eweis, Ibrahim; Correlation between Bone Mineral Density and Urine Carboxyl Terminal of Collagen Type (CTX) in Premenopausal Fibromyalgia Patients. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :798