Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.


Heart-Rate Recovery Immediately after Graded Exercise in Woman with Systemic Lupus Erythematosus.

Prado1,  Danilo M. L., Baptista1,  Fabio, Miossi1,  Renata, Lima1,  Fernanda R., Pinto1,  Ana Lucia S., Borba3,  Eduardo F., Bonfa2,  Eloisa

USP, Sao Paulo, SP, Brazil
USP, Sao Paulo, Brazil
USP

Patients with systemic lupus erythematosus (SLE) are known to have lower heart rate variability suggesting impaired autonomic modulation. Heart-rate recovery after maximal graded exercise test has been identified as a strong independent predictor of cardiovascular and all-cause mortality in adults. Previous studies suggested that low heart-rate recovery is in part due to attenuated parasympathetic reactivation and sympathetic overactivity following the termination of exercise. Besides this knowledge, there is little information about this issue in SLE.

Purpose:

To evaluate the heart-rate recovery after graded exercise in SLE.

Methods:

Eighteen consecutive SLE women (SLE group) with low SLEDAI scores (1.0 ± 2.3) without cardiopulmonary involvement were selected and compared to 17 healthy women (control). All subjects performed a progressive treadmill cardiopulmonary test until exhaustion to determine the maximal aerobic capacity. Heart rate recovery at both one minute (DHRR1) and two minutes (DHRR2) were defined as the difference between heart rate at peak of exercise and at 1 and 2 minutes post exercise, respectively.

Results:

Age (29.6 ± 1.3 vs. 26.2 ± 1.5 years, p=0.10) and Body-mass index (23.7 ± 0.8 vs. 21.8 ± 0.5 kg/m2, p=0.09) were alike between SLE and control group. SLE had significant lower peak workload (4.6±0.1 vs. 5.6±0.0 mph, P=0.001) and relative lower aerobic fitness [VO2peak] (28.3±1.0 vs. 37.1±1.2 mL.kg-1.min-1, P=0.001) compared to control.

 Heart Rate Recovery Post Graded Exercise
 SLEControlP value
(DHRR1)25.9 ± 1.532.7 ± 2.00.01
(DHRR2)41.7 ± 1.652.1 ± 2.10.001
Values are means ± SE. DHRR1 - heart rate recovery at one minute; DHRR2 - heart rate recovery at two minutes. (Unpaired students T Test). P < 0.05 considered statiscally significant.

Conclusion:

These findings demonstrated that woman with SLE had reduced heart rate recovery at first and second minutes after graded exercise compared to controls. Taken together, these data suggest abnormal restoration of autonomic nervous tone including a decrease in vagal tone and an increase in sympathetic activity after graded exercise in these patients.

To cite this abstract, please use the following information:
Prado, Danilo M. L., Baptista, Fabio, Miossi, Renata, Lima, Fernanda R., Pinto, Ana Lucia S., Borba, Eduardo F., et al; Heart-Rate Recovery Immediately after Graded Exercise in Woman with Systemic Lupus Erythematosus. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :626
DOI: 10.1002/art.28394

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