Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.


Frequency of Iridocyclitis at Onset in a Large Series of Patients with Early Psoriatic Arthritis.

Cantini2,  Fabrizio, Nannini2,  Carlotta, Cassara2,  Emanuele, Kaloudi2,  Olga, Susini1,  Massimo, Niccoli2,  Laura

Ophthalmology Unit, Hospital of Prato, Prato, Tuscany, Italy
Rheumatology Unit, Hospital of Prato, Prato, Tuscany, Italy

Background:

The occurrence of iridocyclitis (IC) in early psoriatic arthritis (PsA) has been rarely assessed 1,2.

Objective:

Primary end-point was to evaluate the frequency of IC at onset in a large cohort of p. with early PsA.

Methods:

We evaluated the frequency of IC in a clinical series of consecutive, new outpatients with early PsA observed between January 2000 and December 2009. All p. met the CASPAR criteria for PsA and had a disease duration <=12 months. The demographic and clinical information were stored in a computed database. At baseline sex, age at diagnosis, date of diagnosis, articular and extra-articular manifestations, laboratory assessments [erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), HLA B27], radiological evaluation (sacro-iliac joints X-ray, and MRI), were assembled. The following clinical patterns were considered: peripheral PsA (oligoarthritis <=4 and polyarthritis >=5 involved joints), axial PsA (Calin's criteria for inflammatory spinal pain, radiographic or MRI evidence of sacroiliitis), mixed (concomitant axial and peripheral features). IC diagnosis was accepted in presence of typical ocular signs/symptoms and ophthalmology examination. Therapy was standardized as previously reported3. P. were followed by the same rheumatologist, and follow-up visits were scheduled at baseline and every 4 months. Control visit intervals were shortened in the case of urgent clinical problems, and all p. were instructed to call the centre in presence of worsening of previous arthritis, additional joint involvement, extra-articular manifestations onset, adverse events (AEs).

Results:

242 p., 137 (57%) women and 105 (43%) men with a mean age of 50.33±11.7 ys and a mean duration of symptoms of 9.38±3.1 months were studied. Peripheral pattern was observed 132 (51%) p., axial in 41 (17%) and mixed in 69 (28%). Mean ESR and CRP were 31±18 mm/h and 1.83±2.28 mg/dl respectively. A total number of 26 episodes of IC were recorded at diagnosis in 22 (9%) p., 17 (77.3%) females and 5 (22.7%) males; 11 (50%) p. had peripheral PsA, 2 (9.1%) axial and 9 (40.9%) mixed; 5/22 (22.7%) p. were B27 positive. IC recurred in 2/22 (9%) p. over the follow up. Mean follow-up duration was 4.6±3.5 years. Multiple logistic regression analysis did not disclose any significant association with IC for all demographic, clinical, and laboratory variables.

Conclusion:

IC occurred in 9% of 242 p. with early PsA. This frequency is higher than previously reported. IC was not associated with the PsA clinical pattern and B27 positivity.

References

1.Kane, D et al. Rheumatology (Oxford) 2003; 42: 1460-8.

2.Jones, SM, et al. Br J Rheumatol 1994; 33: 834-9.

3.Cantini, F, et al. Rheumatology (Oxford) 2008; 47: 872-6.

To cite this abstract, please use the following information:
Cantini, Fabrizio, Nannini, Carlotta, Cassara, Emanuele, Kaloudi, Olga, Susini, Massimo, Niccoli, Laura; Frequency of Iridocyclitis at Onset in a Large Series of Patients with Early Psoriatic Arthritis. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :528
DOI: 10.1002/art.28297

Abstract Supplement

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