Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Morphological Changes in Articular Cartilage and Subchondral Bone in Tibiofemoral and Patellofemoral Joints Following Arthroscopic Partial Medial Meniscectomy.
Wang2, Yuanyuan, Dempsey3, Alasdair, Lloyd3, David, Mills1, Peter, Wrigley4, Tim, Bennell4, Kim, Metcalf4, Ben
Although meniscectomy is an important risk factor for tibiofemoral osteoarthritis (OA), there is a paucity of studies examining the relationship between meniscectomy and patellofemoral OA. This study aimed to examine the morphological changes in articular cartilage and subchondral bone in tibiofemoral and patellofemoral joints in a meniscectomy population.
158 patients aged 3055 years, without evidence of knee OA when undergoing isolated arthroscopic partial medial meniscectomy (APMM), and 38 controls with similar characteristics with APMM patients but without the surgery were recruited. Magnetic resonance imaging (MRI) of the operated knee was obtained at 3 months, 2 years, or 4 years post-surgery. MRI of the randomly assigned knee of the controls was also obtained. Cartilage volume and cartilage defects, bone area or volume were assessed using validated methods in tibiofemoral and patellofemoral compartments.
Summary of Results:
Compared with controls, patients undergoing APMM had an increased prevalence of cartilage defects in the medial tibiofemoral (OR = 3.17, 95% CI 1.24 8.11, P = 0.02) and patellofemoral (OR = 13.76, 95% CI 1.52 124.80, P = 0.02) compartments, and increased medial tibial plateau bone area (B = 143.8, 95% CI 57.4 230.2, P = 0.001). Time from APMM was positively associated with the prevalence of cartilage defects in the medial tibiofemoral (OR = 1.02, 95% CI 1.00 1.03, P = 0.09) and patellofemoral (OR = 1.04, 95% CI 1.01 1.07, P = 0.02) compartments, and medial tibial plateau area (B = 2.5, 95% CI 0.8 4.3, P = 0.005), but negatively associated with lateral tibial cartilage volume (B =-4.9, 95% CI -8.4 to -1.5, P = 0.005). The association of APMM and time from APMM with patellar cartilage defects was independent of medial tibial cartilage volume.
Meniscectomy has adverse impacts on both tibiofemoral and patellofemoral joints within 5 years post-surgery. Strategies aimed at preventing the development of OA and reducing morbidity in meniscectomy populations should focus on both tibiofemoral and patellofemoral joints.
To cite this abstract, please use the following information:
Wang, Yuanyuan, Dempsey, Alasdair, Lloyd, David, Mills, Peter, Wrigley, Tim, Bennell, Kim, et al; Morphological Changes in Articular Cartilage and Subchondral Bone in Tibiofemoral and Patellofemoral Joints Following Arthroscopic Partial Medial Meniscectomy. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :192