Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.


Adiponectin but Not Leptin and Resistin, Is Associated with the Progression of Hand Osteoarthritis.

Yusuf1,  Erlangga, Ioan-Facsinay2,  Andreea, Bijsterbosch2,  Jessica, Kwekkeboom2,  Joanneke, Slagboom2,  P. Eline, Huizinga2,  Tom W. J., Kloppenburg2,  Margreet

LUMC, The Netherlands
LUMC, The Netherlands

Purpose:

The link between obesity and osteoarthritis (OA) may be explained by the increased joint stress accompanying obesity. However, it does not explain why being obese is also associated with OA in non-weight-bearing joints, such as the hands. It is suggested that systemic products of fat with systemic metabolic activity (adipokines) may influence the onset and/or progression of osteoarthritis. We investigated here the association between three most common adipokines: leptin, adiponectin and resistin and the progression of hand OA.

Methods:

We selected patients with radiographic hand OA from a cohort consisted of Caucasian sibs with symptomatic OA at multiple sites. We defined hand OA as Kellgren and Lawrence score >=2 in at least two from 20 hand joints (four proximal interphalangeal joints (PIP's), four distal interphalangeal joints (DIP's), one interphalangeal (IP-1) and one carpometacarpal (CMC-1) on each hand). Using the Osteoarthritis Research Society International atlas, the baseline and 6-years follow-up radiograph were assessed for the joint space narrowing (JSN, grade 0 to 3: 0 normal, 3: severe narrowing) of 20 joints (four DIP's, four PIP's, one IP-1 and one CMC-1) per patient. JSN reflects articular cartilage damage. The radiographs were assessed by two readers in consensus and the intra-class correlation coefficient for intra-reader reproducibility based on 25 randomly selected pairs of radiographs was high (0.87). Progression was defined as a change in JSN above the smallest detectable change (SDC) of 2, reflecting change above measurement error. Baseline serum adiponectin concentration was measured by Bio-Plex Pro Assay (Bio-Rad, USA). With logistic regression analysis odds ratios of hand OA progression were computed and transformed to risk ratio (RRs). Adjustments for confounders as age, sex, body mass index (BMI) and family effect were made. We categorized all adipokines in tertiles.

Results:

Complete follow-up data were available from 164 patients out of 248 included patients, (66%, mean age [SD]: 60 [7] years, 81% female, mean BMI [SD]: 27 [5] kg/m2). Fifety-five patients showed hand OA progression. BMI was positively correlated with leptin (Pearson's correlation coefficient, r=0.3) and resistin (r=0.2) and negatively correlated with adiponectin (r=-0.2). Leptin, adiponectin and resistin did not significantly correlate to each other. BMI was not associated with radiographic hand OA progression (b-regression coefficient -0.04 (95% confidence interval -0.08 to 0.05). The association between adipokines and progression of hand OA is shown in the Table.

AdiponectinRisk Ratio (95% Confidence Interval)Risk Ratio (95% Confidence Interval) after adjustment for age, sex, BMI and family effect
Leptin (ng/mL)  
  <4.41 (reference)1 (reference)
  4.41 to 8.20.7 (0.3 to 1.6)0.7 (0.3 to 1.5)
  >8.21.1 (0.5 to 2.3)1.2 (0.4 to 2.5)
Adiponectin (mg/mL)  
  <16.61 (reference)1 (reference)
  16.6 to 28.40.3 (0.1 to 0.7)‡0.2 (0.1 to 0.5)‡
  >28.40.3 (0.1 to 0.6)‡0.2 (0.1 to 0.5)‡
Resistin (ng/mL)  
  <0.81 (reference)1 (reference)
  0.8 to 1.41.0 (0.4 to 2.1)0.9 (0.4 to 1.8)
  >1.40.8 (0.4 to 1.7)0.7 (0.3 to 1.5)
‡Statistical significant at p<0.05

Conclusions:

We show for the first time a substantial inverse association between serum adiponectin levels and radiographic worsening of hand OA. Further studies on the use of adiponectin as biological markers for OA progression and studies on the biological role of adiponectin in OA are needed.

To cite this abstract, please use the following information:
Yusuf, Erlangga, Ioan-Facsinay, Andreea, Bijsterbosch, Jessica, Kwekkeboom, Joanneke, Slagboom, P. Eline, Huizinga, Tom W. J., et al; Adiponectin but Not Leptin and Resistin, Is Associated with the Progression of Hand Osteoarthritis. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :179
DOI: 10.1002/art.27948

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