Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement
Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.
Inflammatory Osteophyte Formation Is Different from Degenerative Osteophyte Formation.
Finzel, Stephanie, Ernet, Christian, Stach, Christian, Engelke, Klaus, Englbrecht, Matthias, Schett, Georg
To investigate the differences in the pattern of periarticular oteophyte formation in patients with psoriatic arthritis and hand osteoarthritis by a high-resolution micro-computed tomography scanner (mCT) designed to visualize bone architecture. Both psoriatic arthritis (PSA) and osteoarthrits (OA) lead to joint destruction via deforming osteophytic proliferation but may differ substantially in their periarticular bone changes.
24 patients with PSA and 24 patients age- and sex-matched with OA received a micro- computed tomography scan of the dominantly affected hand to compare structural bone changes in the metacarpophalangeal joints. Number, size and distribution of osteophytes were recorded.
Number and size of osteophytes in PSA were comparable to OA. However osteophytes in OA were exclusively found at the palmar and dorsal sites of the MCP-joints. Moreover, in OA patients the metacarpal heads were by far more affected than the phalangeal bases. In contrast, osteophyte formation in PSA did also involve skeletal sites which are normally spared in OA patients, such as the radial and ulnar sites, usually leading to affection of the entire circumference of the periarticular bone surface ("bony corona"). Also significant affection of the phalangeal bases was observed in PSA in contrast to OA.
High-resolution mCT imaging shows profound differences in periarticular bone changes between PSA and HFE. The differential pattern of osteophyte formation between PSA and OA patient suggest different mechanisms to be involved in bone spur formation in consequence of inflammatory and degenerative arthritis of the finger joints. In particular the wide spread corona- shaped osteophyte formation in PSA suggests a profound involvement of the insertion sides of the tendons which is also supported by a far more severe affection of the phalangeal bases. Theses data suggest that it is possible to differentiate between inflammatory and degenerative osteophyte formation by advanced imaging technology.
To cite this abstract, please use the following information:
Finzel, Stephanie, Ernet, Christian, Stach, Christian, Engelke, Klaus, Englbrecht, Matthias, Schett, Georg; Inflammatory Osteophyte Formation Is Different from Degenerative Osteophyte Formation. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :128