Arthritis & Rheumatism, Volume 62,
November 2010 Abstract Supplement

Abstracts of the American College of
Rheumatology/Association of Rheumatology Health Professionals
Annual Scientific Meeting
Atlanta, Georgia November 6-11, 2010.

Hysterectomy Status and Fibromyalgia Symptom Severity.

O. Whipple,  Mary, Vincent,  Ann, H. Oh,  Terry, A. Luedtke,  Connie, L. Hoskin,  Tanya


Clinical observation and preliminary studies suggest that gynecological surgeries impact symptom severity in fibromyalgia. However, the literature is deficient in published studies assessing this relationship. Our objective was to compare differences in Fibromyalgia Impact Questionnaire (FIQ) scores in women with fibromyalgia who had a hysterectomy and/or oophorectomy and those who did not.


We conducted a retrospective chart review of 889 women with fibromyalgia, seen in the Fibromyalgia Treatment Program at a tertiary medical center between 2001 and 2004. Patients completed the FIQ at the time of their initial evaluation and data on age, race, duration of fibromyalgia symptoms, hysterectomy status, oophorectomy status and use of hormone therapy was abstracted from the clinical record. Linear regression analysis was used to compare FIQ scores between women who had a hysterectomy and those who did not.


Of the women included in our review, 43.4% had a hysterectomy, 29.7% had a bilateral oophorectomy and 4.3% had a unilateral oophorectomy. After adjusting for age, duration of fibromyalgia symptoms and use of hormone therapy, total FIQ scores of women who had a hysterectomy were significantly higher than those who did not (p=.0013). Similarly, FIQ subscales of physical impairment (p=.0405), pain (p=.0001), stiffness (p=.0397) and depression (p=.0079) were also higher in women who had a hysterectomy than in those who did not. Though not statistically significant, trends were also observed in subscales of fatigue (p=.0979) and anxiety (p=.0517). These associations were independent of oophorectomy status and the timing of the hysterectomy.


Our results indicate that presence of hysterectomy influences symptom severity in women with fibromyalgia. The prevalence of hysterectomy is also higher than the rate of approximately 33% by age 60 reported in general population. To our knowledge, this is the first retrospective review assessing this relationship. Since, our retrospective review was limited by incomplete information on duration of hormone therapy use in relationship to timing of hysterectomy, we are unable to speculate on the influence of surgical menopause on FIQ scores. A prospective study with longitudinal follow-up will better characterize this influence.

To cite this abstract, please use the following information:
O. Whipple, Mary, Vincent, Ann, H. Oh, Terry, A. Luedtke, Connie, L. Hoskin, Tanya; Hysterectomy Status and Fibromyalgia Symptom Severity. [abstract]. Arthritis Rheum 2010;62 Suppl 10 :104
DOI: 10.1002/art.27873

Abstract Supplement

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