Arthritis & Rheumatism, Volume 60,
October 2009 Abstract Supplement
The 2009 ACR/ARHP Annual Scientific Meeting
Philadelphia October 16-21, 2009.
Genetically Determined Mannose-Binding Lectin Deficiency Is Associated with Subclinical Atherosclerosis in Patients with Pediatric-Onset Systemic Lupus Erythematosus
Mannose-binding lectin (MBL) is an innate immune protein. The aim of this study was to determine whether genetically determined MBL deficiency is associated with subclinical atherosclerosis in pediatric-onset systemic lupus erythematosus (SLE).
Between 2002 and 2009, forty-five patients with pediatric-onset SLE and 38 normal controls were recruited. In patients with SLE, prospectively longitudinal carotid ultrasonography was performed to assess subclinical atherosclerosis. MBL2 gene mutations were determined by polymerase chain reaction method and sequence analysis to identify genotypes of MBL. Functional MBL plasma concentrations were detected using enzyme-linked immunosorbent assay. Subclinical atherosclerosis was defined as intima-media thickness (IMT) of carotid artery greater than +1 standard deviation of normal controls. Associations between clinical and laboratory variables and MBL genotypes were determined by simple regression analysis, Mann-Whitney and chi-square tests.
The high, medium and low MBL expression genotype groups were associated with MBL plasma concentrations (3610±6396 ng/ml vs. 580±474 ng/ml vs. undetectable, P < 0.01). The patients with subclinical atherosclerosis and thickening of IMT had lower MBL plasma concentrations on diagnosis of SLE than others (983±808 ng/ml vs. 3560±6716 ng/ml, P= 0.034 and 936±958 ng/ml vs. 2504±4834 ng/ml, P= 0.03, respectively). The high MBL expression genotype was associated with less subclinical atherosclerosis compared to the medium MBL expression genotype (30.8% vs. 62.5%, P= 0.04).
High MBL expression genotype was a protective factor to subclinical progression of atherosclerosis in patients with pediatric-onset SLE. Low MBL level at diagnosis of SLE was a risk factor to the subclincal atherosclerosis.
To cite this abstract, please use the following information:
Huang, Jing-Long; Genetically Determined Mannose-Binding Lectin Deficiency Is Associated with Subclinical Atherosclerosis in Patients with Pediatric-Onset Systemic Lupus Erythematosus [abstract]. Arthritis Rheum 2009;60 Suppl 10 :1569