Arthritis & Rheumatism, Volume 60,
October 2009 Abstract Supplement

The 2009 ACR/ARHP Annual Scientific Meeting
Philadelphia October 16-21, 2009.


A Brachial-Ankle Pulse Wave Velocity Is Affected by the Level of Serum Amyloid A in Patients with Systemic Lupus Erythematosus

Moriguchi,  Masato, Kamiya,  Yurika, Sakurai,  Tadashi, Terai,  Chihiro

Purpose:

Systemic lupus erythematosus (SLE) is associated with increased premature cardiovascular (CV) morbidity and mortality. For estimating CV risk, several techniques, such as electron beam CT scanning, myocardial perfusion imaging, and cervical ultrasonography were developed. However, these modalities are expensive and time-consuming methods. Pulse wave velocity (PWV) is a gold-standard measure of arterial stiffness closely associating with CV risk. Brachial-ankle PWV (baPWV) measure can be performed more easily and repeatedly and is more suitable for screening in general out-patients clinics. Using baPWV measure, we analyzed arterial stiffness of SLE patients and determined the clinical variables affecting CV risk of SLE.

Method:

Seventy-six female SLE patients fulfilled ACR criteria and 54 age-matched healthy female controls were enrolled in this cross-sectional observation study. Written informed consent was obtained from every patient and control. Using form PWV/ABI, baPWV were measured in all subjects and were compared between SLE group and control. In SLE group, clinical features (age, BMI, blood pressure, duration of SLE, smoking history and SLEDAI), laboratory data (C-reactive protein, serum amyloid A, lipid profile, HbA1c, C3, C4 and serum creatinine) and treatments (dose of corticosteroid and use of immunosuppressants) were assessed simultaneously. Stepwise multiple regression analysis was performed to determine the variables affecting baPWV in SLE patients.

Results:

Mean baPWV of SLE patients was significantly higher than that of healthy controls (1353±275 versus 1214±154cm/sec, p<0.0005). Stepwise multiple regression analysis showed that systolic blood pressure, level of serum amyloid A (SAA), and use of immunosuppressants significantly affected baPWV in patients with SLE (b=0.66; t-value=8.74; P<0.0001, b=0.20; t-value=2.68; P=0.0125, and b=0.17; t-value=2.54; P=0.0136, respectively). Also the multiple linear regression analysis showed that SAA levels in SLE were significantly influenced from SLEDAI score (b=0.57, t-value=5.08, P<0.0001).

Conclusion:

This study indicated that arterial stiffness of SLE correlated with both classic CV risk factor, especially hypertension, and inflammation due to SLE per se. Not C-reactive protein but SAA may reflect active status of SLE.

To cite this abstract, please use the following information:
Moriguchi, Masato, Kamiya, Yurika, Sakurai, Tadashi, Terai, Chihiro; A Brachial-Ankle Pulse Wave Velocity Is Affected by the Level of Serum Amyloid A in Patients with Systemic Lupus Erythematosus [abstract]. Arthritis Rheum 2009;60 Suppl 10 :1565
DOI: 10.1002/art.26639

Abstract Supplement

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