Arthritis & Rheumatism, Volume 60,
October 2009 Abstract Supplement
The 2009 ACR/ARHP Annual Scientific Meeting
Philadelphia October 16-21, 2009.
Relationships Between Presence, Severity, and Location of Prevalent Vertebral Fractures and Health Related Quality of Life (HRQoL)
Silverman1, S., Viswanathan2, H., Yang2, Y., Eis3, S.R., Fardellone4, P., Gilchrist5, N., Lips6, P.
Cedars Sinai/UCLA, Beverly Hills, CA,
United Biosource Corporation, Bethesda, MD,
Women's Health Research Center, Laurel, MD,
Columbia University Medical Center, New York, NY
Amgen Inc., Thousand Oaks, CA,
CEDOES Diagnóstico e Pesquisa, Vitória, Brazil,
Hôpital Nord, Amiens, France,
Princess Margaret Hospital, Christchurch, New Zealand,
VU University Medical Center, Amsterdam, Netherlands,
University of California San Francisco, San Francisco, CA,
Palacios Institute of Women's Health, Madrid, Spain,
Charles University, Prague, Czech Republic,
Purpose:
The objectives were to examine 1) the relationship between presence of prevalent vertebral fractures and HRQoL in the FREEDOM trial, and 2) the relationships between number, location, and severity of prevalent vertebral fractures and HRQoL in women with at least 1 prevalent vertebral fracture.
Methods:
Baseline data from 7,808 women (60–90 years, lumbar spine and/or total hip T-score < -2.5 and not <-4.0) included in the phase 3, denosumab FREEDOM trial were used. Prevalent vertebral fractures were assessed by radiography. The 34-item Osteoporosis Assessment Questionnaire-Short Version (OPAQ-SV) was used to measure physical function, emotional status, and back pain with higher scores representing better HRQoL (subscale scores range from 0 to 100). Multiple regression was used to examine relationships between prevalent vertebral fractures and OPAQ-SV scores in all women, and relationships between number, location, fracture severity, and OPAQ-SV scores in women with at least 1 prevalent vertebral fracture, adjusting for age, race, region, and body mass index.
Results:
Presence of one vertebral fracture vs no fracture was significantly associated with worse physical function (coefficient [coeff]=-1.3, SE=0.5), emotional status (coeff =-2.0, SE=0.6), and back pain (coeff =-3.0, SE=0.8), adjusting for covariates. Presence of >=2 vs no fracture was significantly associated with worse emotional status (p<0.05) and back pain (p<0.05) but not physical function. In women with at least 1 prevalent vertebral fracture (N=1,844), no differences were found in OPAQ-SV dimensions for those with >=2 (mean [SD], 2.5 [1.1]) vs 1 fracture (Table). Moderate or severe fractures were associated with lower scores in all OPAQ-SV dimensions (p<0.05) compared to mild fractures (Table). Prevalent lumbar (L2 to L4) fractures were associated with significantly lower scores in all OPAQ-SV dimensions (p<0.05) compared to thoracic (T4 to T9) fractures (Table). Thoracolumbar fractures (T10-L1) were associated with worse physical function (p<0.05) compared to thoracic fractures (Table).
Table. Relationships between the number, severity, or location of prevalent vertebral fractures and baseline OPAQ-SV scores in women with at least one prevalent vertebral fracture
Conclusion:
Consistent with published literature, presence of prevalent vertebral fractures was significantly associated with worse physical function, emotional status, and back pain. Moderate or severe prevalent vertebral fractures and those in the lumbar compared to thoracic location showed significantly lower scores in all OPAQ-SV dimensions.
To cite this abstract, please use the following information:
Silverman, S., Viswanathan, H., Yang, Y., Eis, S.R., Fardellone, P., Gilchrist, N., et al; Relationships Between Presence, Severity, and Location of Prevalent Vertebral Fractures and Health Related Quality of Life (HRQoL) [abstract]. Arthritis Rheum 2009;60 Suppl 10 :867
DOI: 10.1002/art.25947
